06-570-AF488 | Anti-phospho Histone H3 (Ser10) Antibody, Alexa Fluor® 488 Conjugate

06-570-AF488
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MICCRbAlexaFluor®488Polyclonal Antibody
      Description
      Catalogue Number06-570-AF488
      DescriptionAnti-phospho Histone H3 (Ser10) Antibody, Alexa Fluor® 488 Conjugate
      Alternate Names
      • H3S10P
      • Histone H3 (phospho Ser10)
      • H3 histone, family 3A
      • H3.3A
      • H3 histone, family 3B
      • H3.3B
      Background InformationHistone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the 'beads on a string' structure. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.
      References
      Product Information
      FormatAlexaFluor®488
      PresentationPurified rabbit conjugate in buffer containing PBS, 15 mg/ml BSA, and 0.1% Sodium Azide.
      Applications
      ApplicationAnti-phospho-H3 (Ser10), Alexa Fluor® 488 Conjugate is a purified rabbit polyclonal that detects Histone H3 phosphorylated at serine 10. This Ab is labeled with Alexa Fluor 488 and validated in IC. The unconjugated version of this antibody is highly published and proven in ICC, IP & WB.
      Key Applications
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: A 1:50 dilution from a representative lot detected phospho Histone H3 (Ser10) in NIH/3T3 cells.

      Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected Histone H3 (Ser10) in HeLa cell lysate.
      Biological Information
      ImmunogenLinear peptide corresponding to phospho-Histone H3 (Ser10).
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • HIST1H3A
      • H3FA
      • HIST1H3B
      • H3FL
      • HIST1H3C
      • H3FC
      • HIST1H3D
      • H3FB
      • HIST1H3E
      • H3FD
      • HIST1H3F
      • H3FI
      • HIST1H3G
      • H3FH
      • HIST1H3H
      • H3FK
      • HIST1H3I
      • H3FF
      • HIST1H3J
      • H3FJ
      • HIST3H3
      • H3FT
      • H3T
      • MGC126886
      Purification MethodProtein A Purfied
      UniProt Number
      Molecular Weight~17 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunocytochemistry in HeLa cells.

      Immunocytochemistry Analysis: A 1:50 dilution of this antibody detected phospho Histone H3 (Ser10) in HeLa cells.

      Alexa Fluor® is a registered trademark of Life Technologies®.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-phospho Histone H3 (Ser10), -2566795 2566795
      Anti-phospho Histone H3 (Ser10), -2659578 2659578
      Anti-phospho Histone H3 (Ser10), -2712582 2712582
      Anti-phospho Histone H3 (Ser10), Alexa Fluor® 488 Conjugate 2955671
      Anti-phospho Histone H3 (Ser10), Alexa Fluor® 488 Conjugate 2926480
      Anti-phospho Histone H3 (Ser10), Alexa Fluor® 488 Conjugate - Q2411267 Q2411267
      Anti-phospho Histone H3 (Ser10), Alexa Fluor® 488 Conjugate -2538344 2538344
      Anti-phospho Histone H3 (Ser10), Alexa Fluor® 488 Conjugate -2834482 2834482