05-806-AF647 | Anti-phospho Histone H3 (Ser10), clone 3H10, Alexa Fluor® 647 Antibody

05-806-AF647
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HICCMAlexaFluor®647Monoclonal Antibody
      Description
      Catalogue Number05-806-AF647
      DescriptionAnti-phospho Histone H3 (Ser10), clone 3H10, Alexa Fluor® 647 Antibody
      Alternate Names
      • H3S10P
      • Histone H3 (phospho Ser10)
      • H3 histone, family 3A
      • H3.3A
      • H3 histone, family 3B
      • H3.3B
      Background InformationHistone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the 'beads on a string' structure. Histone proteins are highly post-translationally modified, and Histone H3 is the most extensively modified of the five histones. Histone H3 sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes. Di- and tri-methylation of histone H3 are gene silencing marks, while removal of these marks by the demethylase genes Jmjd1a and Jmjd2c leads to gene activation. This product is a conjugated version of Cat. No. 05-806.
      References
      Product Information
      FormatAlexaFluor®647
      PresentationPurified mouse conjugated antibody in buffer containing PBS and 15 mg/ml BSA with 0.1% Sodium Azide.
      Applications
      ApplicationThis Anti-phospho Histone H3 (Ser10) antibody, clone 3H10, Alexa Fluor® 647 is a purified mouse monoclonal for detection of Histone H3 phosphorylated at serine 10.
      This mAb is fluorescently labeled and validated for use in IC. The unconjugated version has been proven in FC, ICC, IF, PIA, WB, Mplex.
      Key Applications
      • Immunocytochemistry
      Biological Information
      ImmunogenLinear peptide corresponding to Histone H3 phosphorylated at Ser10.
      Clone3H10
      HostMouse
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • HIST1H3A
      • H3FA
      • HIST1H3B
      • H3FL
      • HIST1H3C
      • H3FC
      • HIST1H3D
      • H3FB
      • HIST1H3E
      • H3FD
      • HIST1H3F
      • H3FI
      • HIST1H3G
      • H3FH
      • HIST1H3H
      • H3FK
      • HIST1H3I
      • H3FF
      • HIST1H3J
      • H3FJ
      • HIST3H3
      • H3FT
      • H3T
      • MGC126886
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~17 kDa observed (Refer to Cat. No. 05-806)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunocytochemistry Analysis in HeLa cells.

      Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected phospho Histone H3 (Ser10) in HeLa cells.

      Alexa Fluor® is a registered trademark of Life Technologies®.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications