07-852 | Anti-phospho-MEK1 (Thr292) Antibody

07-852
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-852
      Replaces07-348
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-phospho-MEK1 (Thr292) Antibody
      Alternate Names
      • MAP Kinase Kinase 1
      • MAPK/ERK Kinase 1
      • MAPKK1
      • MAP2K1
      References
      Product Information
      FormatAffinity Purified
      Presentation100 μL of affinity purified rabbit polyclonal IgG in 50% storage buffer (PBS (without Mg2+ and Ca2+), pH 7.3 containing 1.0 mg/mL BSA (IgG, protease free) and 0.05% sodium azide) and 50% glycerol.
      Applications
      ApplicationAnti-phospho-MEK1 (Thr292) Antibody is an antibody against phospho-MEK1 (Thr292) for use in WB.
      Key Applications
      • Western Blotting
      Application NotesImmunoblot Analysis: A 1:1000 dilution of this lot detected phosphorylated MEK1 (Thr292) in RIPA lysates of untreated A431 cells.
      Biological Information
      ImmunogenPeptide corresponding to amino acid region encompassing the human, mouse, rat and hamster phospho-MEK1 (Thr292).
      HostRabbit
      SpecificityRecognizes phospho-MEK1 (Thr292).
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.
      Gene Symbol
      • MAP2K1
      • MAPKK1
      • PRKMK1
      • MEK1
      • MKK1
      Modifications
      • Phosphorylation
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q02750 # Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.
      SIZE: 393 amino acids; 43439 Da
      SUBUNIT: Interacts with MORG1 (By similarity). Interacts with Yersinia yopJ.
      PTM: Phosphorylation on Ser/Thr by MAP kinase kinase kinases (RAF or MEKK1) regulates positively the kinase activity. & Acetylation by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.
      DISEASE: SwissProt: Q02750 # Defects in MAP2K1 are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio- cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant.
      SIMILARITY: SwissProt: Q02750 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. & Contains 1 protein kinase domain.
      Molecular Weight~44 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-phospho-MEK1 (Thr292) 3076535
      Anti-phospho-MEK1 (Thr292) (Affinity purified Rabbit polyclonal IgG) - 2387484 2387484
      Anti-phospho-MEK1 (Thr292) (Affinity purified Rabbit polyclonal IgG) - 2390384 2390384
      Anti-phospho-MEK1 (Thr292) (Affinity purified Rabbit polyclonal IgG) 2883129
      Anti-phospho-MEK1 (Thr292) (Affinity purified Rabbit polyclonal IgG) 3094655
      Anti-phospho-MEK1 (Thr292) (Affinity purified Rabbit polyclonal IgG) - 1967324 1967324
      Anti-phospho-MEK1 (Thr292) (Affinity purified Rabbit polyclonal IgG) - 2199557 2199557
      Anti-phospho-MEK1 (Thr292) (Affinity purified Rabbit polyclonal IgG) - 2219321 2219321
      Anti-phospho-MEK1 (Thr292) (Affinity purified Rabbit polyclonal IgG) - DAM1487534 DAM1487534
      Anti-phospho-MEK1 (Thr292) (Affinity purified Rabbit polyclonal IgG) - NG1950811 NG1950811

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies