06-1333 | Anti-phospho-TAB1 (Ser438) Antibody

06-1333
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, H, R, Ox, EqWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number06-1333
      DescriptionAnti-phospho-TAB1 (Ser438) Antibody
      Alternate Names
      • TGF-beta activated kinase 1/MAP3K7 binding protein 1
      • TAK1-binding protein 1
      • transforming growth factor beta-activated kinase-binding protein 1
      • mitogen-activated protein kinase kinase kinase 7 interacting protein 1
      • Mitogen-activated protein kinase kinase kinase 7-interacting protein 1
      • 3'-Tab1
      • TGF-beta-activated kinase 1-binding protein 1
      • TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
      Background InformationTAK1 binding protein 1 (TAB1) is thought to activate TAK1 MAPKKK in transforming growth factor-beta (TGF-beta) signaling. TAB1 can also associate with TAK1 to form a unique MAPKKK complex that is thought to activate AP-1 and the NFkappaB signaling pathways. Through conformational changes, TAB1 is also thought to induce p38alpha autophosphorylation. It has been linked to both IL-1alpha and TNFalpha signaling and therefore may also be involved in the inflammatory response. Recent research has found that the TAK1-TAB1 complex may have anti-inflammatory effects by aiding stercurensin in regulating the NFκB-dependent inflammatory pathways.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Lambda phosphatase untreated and treated RAW264.7 cell lysates
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-phospho-TAB1 (Ser438) Antibody is an antibody against phospho-TAB1 (Ser438) for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human TAB1 when phosphorylated at Ser438.
      EpitopePhosphorylated Ser438
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes TAB1 when phosphorylated at Ser438.
      Species Reactivity
      • Mouse
      • Human
      • Rat
      • Ox
      • Horse
      Species Reactivity NoteDemonstrated to react with mouse. Predicted to react with human, rat, ox, and equine based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq].
      Gene Symbol
      • TAB1
      • MAP3K7IP
      Modifications
      • Phosphorylation
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.

      SUBUNIT STRUCTURE: Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2.

      TISSUE SPECIFICTY: Ubiquitous.

      PTM: Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP.

      SEQUENCE SIMILARITIES: Contains 1 PP2C-like domain.
      Molecular Weight ~72/58 kDa observed. ~56 kDa calculated. The observed kDa may be due to glycosylation. (Ohkusu-Tsukada, K., et al. (2010). Eur. J. Immunol. 40:1011–1021.) An uncharacterized band appears at ~30 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in lambda phosphatase untreated and treated RAW264.7 cell lysates.

      Western Blot Analysis: 01 µg/mL of this antibody detected TAB1 on 10 µg of lambda phosphatase untreated and treated RAW264.7 cell lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies