07-737 | Anti-phospho TRF2 (Thr188) Antibody

07-737
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-737
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-phospho TRF2 (Thr188) Antibody
      References
      Product Information
      FormatAffinity Purified
      Applications
      ApplicationDetect phospho TRF2 (Thr188) with Anti-phospho TRF2 (Thr188) Antibody (Rabbit Polyclonal Antibody), that has been shown to work in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated, synthetic peptide corresponding to amino acids 183-192 (C-SKDPT(pT) QKLR) of human Telomeric Repeat binding Factor2 (TRF2) with a N-terminal cysteine added for conjugation purposes
      HostRabbit
      SpecificityRecognizes phospho-TRF2 (Thr188)
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic.
      Gene Symbol
      • TERF2
      • TRBF2
      • TRF2
      Modifications
      • Phosphorylation
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q15554 # Binds the telomeric double-stranded TTAGGG repeat. Protects against end-to-end fusion of chromosomes and plays a role in successful progression through the cell division cycle.
      SIZE: 500 amino acids; 55551 Da
      SUBUNIT: Homodimer. Binds to RAP1. Interacts with NBN.
      SUBCELLULAR LOCATION: Nucleus. Note=Colocalizes with telomeric DNA in interphase cells and is located at chromosome ends during metaphase.
      TISSUE SPECIFICITY: Ubiquitous. Highly expressed in spleen, thymus, prostate, uterus, testis, small intestine, colon and peripheral blood leukocytes.
      PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
      SIMILARITY: SwissProt: Q15554 ## Contains 1 HTH myb-type DNA-binding domain.
      Molecular Weight64kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies