07-1513 | Anti-phospho-WAVE2 (Thr346) Antibody

100 µg  
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      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, Mk, M, RWBRbAffinity PurifiedPolyclonal Antibody
      Catalogue Number07-1513
      DescriptionAnti-phospho-WAVE2 (Thr346) Antibody
      Alternate Names
      • Wiskott-Aldrich syndrome protein family member 2
      • WASP family protein member 2
      • Protein WAVE-2
      • Verprolin homology domain-containing protein 2
      Background InformationWiskott-Aldrich Syndrome Protein (WASP)-family Protein Member 2 (known as WAVE2) has a very wide distribution with strong expression in peripheral blood leukocytes. WAVE2 is involved in signaling RTKs and small GTPases. In general WAVE family of proteins have a general function for regulating the actin cytoskeleton in various tissues.
      Product Information
      FormatAffinity Purified
      • EGF-treated COS cells that are untreated and treated with lambda phosphatase
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationThis Anti-phospho-WAVE2 (Thr346) Antibody is validated for use in WB for the detection of phospho-WAVE2 (Thr346).
      Key Applications
      • Western Blotting
      Application NotesWestern Blot Analysis: A previous lot of this antibody was used in WB to detect phospho-WAVE2 (Thr346) in 293T cells transfected with WAVE2 (Mendoza, M., et al. (2011). Molecular Cell 41:661–671).
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human WAVE2 phosphorylated at Thr346.
      EpitopePhosphorylated Thr346
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityThis antibody recognizes WAVE2 phosphorylated at Thr346.
      Species Reactivity
      • Human
      • Monkey
      • Mouse
      • Rat
      Species Reactivity NoteDemonstrated to react with Monkey and Human.
      Predicted to react with Rat and Mouse based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
      Gene Symbol
      • WASF2
      • WAVE2
      • Phosphorylation
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton.

      SUBUNIT STRUCTURE: Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Directly interacts with C3orf10/HSPC300.

      SUBCELLULAR LOCATION: Cytoplasm › cytoskeleton (By similarity). Cell projection › lamellipodium (By similarity). Note: At the interface between the lamellipodial actin meshwork and the membrane (By similarity).

      TISSUE SPECIFICTY: Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle.

      DOMAIN: Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.

      SEQUENCE SIMILARITIES: Belongs to the SCAR/WAVE family.

      Contains 1 WH2 domain.
      Molecular Weight~84 kDa observed. In WB, band runs at ~84 kDa (Yan, C., et al. (2003). EMBO. 22:3602-3612) , despite having a calculated MW of ~54 kDa.
      An uncharacterized band appears ~150 kDa in some lysates.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in EGF-treated COS cells that are untreated and treated with lambda phosphatase.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected phospho-WAVE2 (Thr346) in 10 µg of EGF-treated COS cells that are untreated and treated with lambda phosphatase.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-phospho-WAVE2 (Thr346) - 2344725 2344725
      Anti-phospho-WAVE2 (Thr346) - NRG1878692 NRG1878692
      Anti-phospho-WAVE2 (Thr346) -2567147 2567147
      Anti-phospho-WAVE2 (Thr346)_2845525 2845525


      Reference overviewPub Med ID
      ERK-MAPK drives lamellipodia protrusion by activating the WAVE2 regulatory complex.
      Mendoza, MC; Er, EE; Zhang, W; Ballif, BA; Elliott, HL; Danuser, G; Blenis, J
      Molecular cell  41  661-71  2011

      Show Abstract
      21419341 21419341

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      Life Science Research > Antibodies and Assays > Primary Antibodies