04-393 | Anti-phospho-p70 S6 Kinase (Thr421/Ser424) Antibody, rabbit monoclonal

04-393
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIP, WBRbPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-393
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-phospho-p70 S6 Kinase (Thr421/Ser424) Antibody, rabbit monoclonal
      Alternate Names
      • RPS6KB1 ribosomal protein S6 kinase
      • 70kDa
      • PS6K
      • S6K
      • S6K1
      • STK14A
      • p70(S6K)-alpha
      • p70-S6K
      • p70-alpha
      References
      Product Information
      FormatPurified
      Presentation100 μL of rabbit monoclonal IgG in 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.
      Applications
      ApplicationThis Anti-phospho-p70 S6 Kinase (Thr421/Ser424) Antibody, rabbit is validated for use in IP, WB for the detection of phospho-p70 S6 Kinase (Thr421/Ser424).
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated synthetic peptide corresponding to the region surrounding Thr421 and Ser424 of human p70 S6 Kinase.
      HostRabbit
      SpecificityRecognizes the p70 S6 Kinase when phosphorylated on Thr421 and Ser424.
      IsotypeIgG
      Species Reactivity
      • Human
      Species Reactivity NoteNot believed to react with mouse or rat.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.
      Gene Symbol
      • RPS6KB1
      • p70-alpha
      • p70S6k
      • p70-S6K
      • p70
      • S6K
      • S6Kalpha)
      • P70S6K
      • STK14A
      • S6K1
      • p70(S6K)-alpha
      • PS6K
      Modifications
      • Phosphorylation
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P23443 # Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens.
      SIZE: 525 amino acids; 59140 Da
      SUBUNIT: Interacts with PPP1R9A/neurabin-1 (By similarity).
      SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell junction, synapse, synaptosome (By similarity).
      TISSUE SPECIFICITY: Widely expressed.
      SIMILARITY: SwissProt: P23443 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 protein kinase domain.
      Molecular Weight70 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-phospho-p70 S6 Kinase (Thr421/Ser424), Rabbit Monoclonal (Rabbit monoclonal IgG) - 2377660 2377660
      Anti-phospho-p70 S6 Kinase (Thr421/Ser424), Rabbit Monoclonal (Rabbit monoclonal IgG) - 2435086 2435086
      Anti-phospho-p70 S6 Kinase (Thr421/Ser424), Rabbit Monoclonal (Rabbit monoclonal IgG) - 2193212 2193212
      Anti-phospho-p70 S6 Kinase (Thr421/Ser424), Rabbit Monoclonal - 2029116 2029116
      Anti-phospho-p70 S6 Kinase (Thr421/Ser424), Rabbit Monoclonal - 2068515 2068515
      Anti-phospho-p70 S6 Kinase (Thr421/Ser424), Rabbit Monoclonal - DAM1790585 DAM1790585
      Anti-phospho-p70 S6 Kinase (Thr421/Ser424), Rabbit Monoclonal - NG1944012 NG1944012
      Anti-phospho-p70 S6 Kinase (Thr421/Ser424), rabbit monoclonal - 0611045816 0611045816
      Anti-phospho-p70 S6 Kinase (Thr421/Ser424), rabbit monoclonal - DAM1421467 DAM1421467
      Anti-phospho-p70 S6 Kinase (Thr421/Ser424), rabbit monoclonal - JBC1371287 JBC1371287

      References

      Reference overviewApplicationPub Med ID
      Learned stressor resistance requires extracellular signal-regulated kinase in the prefrontal cortex.
      Christianson, JP; Flyer-Adams, JG; Drugan, RC; Amat, J; Daut, RA; Foilb, AR; Watkins, LR; Maier, SF
      Frontiers in behavioral neuroscience  8  348  2014

      Show Abstract
      Western Blotting25324750 25324750
      A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase 1
      Bachmann, Rebecca A, et al
      J Biol Chem, 281:7357-63 (2006)  2006

      16407298 16407298
      Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control
      Ohanna, Mickael, et al
      Nat Cell Biol, 7:286-94 (2005)  2005

      15723049 15723049
      Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase
      Chiang, Gary G and Abraham, Robert T
      J Biol Chem, 280:25485-90 (2005)  2005

      15899889 15899889

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies