05-861 | Anti-vWF (von Willebrand Factor) Antibody, clone GMA-022

05-861
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-861
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-vWF (von Willebrand Factor) Antibody, clone GMA-022
      References
      Product Information
      FormatPurified
      Applications
      ApplicationAnti-vWF (von Willebrand Factor) Antibody, clone GMA-022 is an antibody against vWF (von Willebrand Factor) for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenPurified human von Willebrand Factor
      CloneGMA-022
      HostMouse
      Specificityvon Willebrand Factor
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22.
      Gene Symbol
      • VWF
      • F8
      • vWF
      • VWD
      • F8VWF
      Purification MethodDEAE purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P04275 # Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
      SIZE: 2813 amino acids; 309299 Da
      SUBUNIT: Multimeric. Interacts with F8.
      SUBCELLULAR LOCATION: Secreted. Note=Localized to storage granules.
      TISSUE SPECIFICITY: Plasma.
      DOMAIN: SwissProt: P04275 The von Willebrand antigen 2 is required for multimerization of VWF and for its targeting to storage granules.
      PTM: All cysteine residues are involved in intrachain or interchain disulfide bonds.
      DISEASE: SwissProt: P04275 # Defects in VWF are associated with various forms of von Willebrand disease (VWD) [MIM:193400, 277480]. VWD is characterized by frequent bleeding (gingival, minor skin quantitative lacerations, menorrhagia, etc.). Type I VWD is associated with a deficiency of VWF; type II by normal to decreased plasma level of VWF; type III by a virtual absence of VWF. There are subtypes (A to H) of type II VWD; for example: type IIA is characterized by the absence of VWF high molecular weight multimers in plasma.
      SIMILARITY: Contains 1 CTCK (C-terminal cystine knot-like) domain. & Contains 4 TIL (trypsin inhibitory-like) domains. & Contains 3 VWFA domains. & Contains 3 VWFC domains. & Contains 4 VWFD domains.
      Molecular Weight260kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-vWF (von Willebrand Factor), clone GMA-022 (mouse monoclonal IgG1) - 2224434 2224434
      Anti-vWF (von Willebrand Factor), clone GMA-022 - 27179 27179
      Anti-vWF (von Willebrand Factor), clone GMA-022 -2668582 2668582

      References

      Reference overviewPub Med ID
      Von Willebrand factor.
      Ruggeri, Zaverio M
      Curr. Opin. Hematol., 10: 142-9 (2003)  2003

      Show Abstract
      12579041 12579041
      Shear stress and von Willebrand factor in health and disease.
      Tsai, Han-Mou
      Semin. Thromb. Hemost., 29: 479-88 (2003)  2003

      Show Abstract
      14631548 14631548

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      Product Families

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies