851004 | BOP

851004
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      Overview

      Replacement Information

      Key Spec Table

      CAS #EC NumberHill FormulaMolar Mass
      56602-33-6260-279-1C₁₂H₂₂N₆OP * F₆P442.28 g/mol

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      8510040025
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          Plastic bottle 25 g
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          8510040100
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              Plastic bottle 100 g
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              Description
              Catalogue Number851004
              Replaces01-62-0001
              Brand Family Novabiochem®
              Alternate Names
              • Benzotriazole-1-yl-oxy-tris-(dimethylamino)-phosphoniumhexafluorophosphate
              • Castro's Reagent
              Background InformationPeptide coupling reagent which suppresses enantiomerization [1-15]. Reduction of carboxylic acids activated with BOP provides a facile route to alcohols [16].

              Novabiochem® recommends the replacement of BOP by PyBOP®(for PyBOP® please see 851009). The manufacture of BOP, as well as its utilization, involves the use or the formation of hexamethylphosphotriamide, the carcinogenicity and respiratory toxicity of which has been the subject of numerous reports.

              The product number for this product was previously 01-62-0001.

              To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
              References
              Product Information
              CAS number56602-33-6
              EC number260-279-1
              Hill FormulaC₁₂H₂₂N₆OP * F₆P
              Molar Mass442.28 g/mol
              HS Code2933 99 80
              Structure formula ImageStructure formula Image
              Applications
              ApplicationBOP Benzotriazole-1-yl-oxy-tris-(dimethylamino)-phosphonium hexafluorophosphate Novabiochem®. CAS 56602-33-6, molar mass 442.28 g/mol.
              Biological Information
              Physicochemical Information
              Melting Point138 - 145 °C
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Hazard Pictogram(s) Hazard Pictogram(s)
              Hazard Pictogram(s)
              Hazard Statement(s)H228: Flammable solid.
              H315: Causes skin irritation.
              H319: Causes serious eye irritation.
              H335: May cause respiratory irritation.
              Precautionary Statement(s)P210: Keep away from heat.
              P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
              P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
              P370 + P378: In case of fire: Use powder for extinction.
              Signal WordWarning
              Storage class10 - 13 Other liquids and solids
              WGKWGK 3 highly water endangering
              Safety Information
              Hazard Symbols Hazard SymbolsFlammable
              Hazard SymbolsIrritant
              Categories of dangerirritant
              R PhraseR 36/37/38-10
              Irritating to eyes, respiratory system and skin.Flammable.
              Product Usage Statements
              Storage and Shipping Information
              StorageStore at +2°C to +8°C.
              Packaging Information
              Transport Information
              Declaration (railroad and road) ADR, RIDUN 1325 , 4.1, III
              Declaration (transport by air) IATA-DGRUN 1325 , 4.1, III
              Declaration (transport by sea) IMDG-CodeUN 1325 , 4.1, III
              Supplemental Information
              Specifications
              Colour (visual)white to slight yellow to beige
              Appearance of substance (visual)powder
              Identity (IR)passes test
              Assay (HPLC, area%)≥ 99.0 % (a/a)
              Solubility (0.6 mmole in 1 ml DMF)clearly soluble

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              Product Number PackagingSpecificationLot Number
              8510040025 Plastic bottlePDF Specification Document
              8510040100 Plastic bottlePDF Specification Document

              Brochure

              Title
              Novabiochem Coupling Reagent Flyer 2010
              Novabiochem Innovations 02/06
              Novabiochem Innovations 03/10
              Novabiochem Letters 01/14

              Citations

              Title
              • [1] B. Castro, et al. (1975) Tetrahedron Lett., 16, 1219.
              • [2] B. Castro, et al. (1976) Synthesis, 751.
              • [3] B. Castro, et al. (1977) Synthesis, 413.
              • [4] B. Castro, et al. (1977) J. Chem. Res. (S), 182.
              • [5] P. Rivaille, et al. (1980) Tetrahedron, 36, 3413.
              • [6] D. L. Nguyen, et al. (1985) J. Chem. Soc., Perkin Trans. 1, 1025.
              • [7] D. L. Nguyen, et al. (1987) J. Chem. Soc., Perkin Trans. 1, 1915.
              • [8] A. Fournier, et al. (1988) Int. J. Peptide Protein Res., 31, 86 and 231.
              • [9] J.-P. Briand, et al. (1989) Pept. Res., 2, 381.
              • [10] A. Fournier, et al. (1989) Int. J. Peptide Protein Res., 33, 133.
              • [11] D. L. Nguyen, et al. (1989) Biochem. Biophys. Res. Commun., 162, 1425.
              • [12] W. K. Rule, et al. in 'Peptides 1988, Proc. 20th European Peptide Symposium', G. Jung & E. Bayer (Eds), Walter de Gruyter, Berlin, 1989, pp. 238.
              • [13] M. Forest, et al. (1990) Int. J. Peptide Protein Res., 35, 89.
              • [14] R. Seyer, et al. (1990) Int. J. Peptide Protein Res., 35, 465.
              • [15] H. Gausepohl, et al. in 'Innovation & Perspectives in Solid Phase Synthesis, 2nd International Symposium', R. Epton (Eds), Intercept UK Ltd., Andover, 1993, pp. 387.
              • [16] R. P. McGeary (1998) Tetrahedron Lett., 39, 3319.