509890 Benztropine - CAS 132-17-2 - Calbiochem

509890
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₂₁H₂NO·CH₃SO₃H132-17-2

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      5.09890.0001
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          Glass bottle 50 mg
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          Description
          OverviewA brain penetrating azabicyclo[3.2.1]octane derivative with anti-cholinergic and anti-histaminergic properties. Acts as an antagonist of muscarinic M1 and M3 receptors induces robust differentiation of oligodendrocytes precursor cell differentiation (OPC; EC50 = 500 nM) and promotes myelination. Reduces the expression of Notch 1 in immature OPC and reduces the levels of cyclin D1 and D2 and c-Fos and c-Jun indicating its inhibitory effect on cell cycle progression. Shown to reduce the severity of the acute phase of multiple sclerosis and virtually eliminates the relapse phase in animal models. Significantly reduces the severity in the experimental autoimmune encephalomyelitis (EAE) model of relapsing-remitting multiple sclerosis when administered alone or co-administered with FTY720 (Cat. No. 344597).
          Catalogue Number509890
          Brand Family Calbiochem®
          SynonymsBenzatropine, Cogentin
          References
          ReferencesDeshmukh, V.A, et al. 2013. Nature 502,327.
          Doshay, L.J., et al. 1956. J Am Med Assoc. 162, 1031.
          Product Information
          CAS number132-17-2
          FormWhite solid
          Hill FormulaC₂₁H₂NO·CH₃SO₃H
          Chemical formulaC₂₁H₂NO·CH₃SO₃H
          ReversibleY
          Applications
          Biological Information
          Primary TargetMuscarinic M1/M3
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 25

          Toxic if swallowed.
          S PhraseS: 36-45

          Wear suitable protective clothing.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          References

          Reference overview
          Deshmukh, V.A, et al. 2013. Nature 502,327.
          Doshay, L.J., et al. 1956. J Am Med Assoc. 162, 1031.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-April-2014 JSW
          SynonymsBenzatropine, Cogentin
          DescriptionA brain penetrating azabicyclo[3.2.1]octane derivative with anti-cholinergic and anti-histaminergic properties. Acts as an antagonist of muscarinic M1 and M3 receptors induces robust differentiation of oligodendrocytes precursor cell differentiation (OPC; EC50 = 500 nM) and promotes myelination. Reduces the expression of Notch 1 in immature OPC and reduces the levels of cyclin D1 and D2 and c-Fos and c-Jun indicating its inhibitory effect on cell cycle progression. Shown to reduce the severity of the acute phase of multiple sclerosis and virtually eliminates the relapse phase in animal models. Significantly reduces the severity in the experimental autoimmune encephalomyelitis (EAE) model of relapsing-remitting multiple sclerosis when administered alone or co-administered with FTY720 (Cat. No. 344597).
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number132-17-2
          Chemical formulaC₂₁H₂NO·CH₃SO₃H
          Purity≥98% by HPLC
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Toxic
          ReferencesDeshmukh, V.A, et al. 2013. Nature 502,327.
          Doshay, L.J., et al. 1956. J Am Med Assoc. 162, 1031.