500112 Cocarboxylase chloride

500112
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      Overview

      Replacement Information

      Key Spec Table

      CAS #EC NumberHill FormulaMolar Mass
      154-87-0205-836-1C₁₂H₁₉ClN₄O₇P₂S460.77 g/mol

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      5001120100
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          Plastic bottle 100 g
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          5001121000
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              Plastic bottle 1 kg
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              5001125000
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                  Plastic bottle 5 kg
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                  Description
                  Catalogue Number500112
                  SynonymsThiaminium diphosphoric acid ester chloride, Thiaminium pyrophosphate chloride, Thiaminium pyrophosphoric acid ester chloride, TPP
                  References
                  Product Information
                  CAS number154-87-0
                  EC number205-836-1
                  Hill FormulaC₁₂H₁₉ClN₄O₇P₂S
                  Molar Mass460.77 g/mol
                  HS Code2936 22 00
                  Structure formula ImageStructure formula Image
                  Applications
                  Biological Information
                  Physicochemical Information
                  Melting Point240 - 244 °C (decomposition)
                  pH value1.0 - 1.4 (100 g/l, H₂O, 20 °C)
                  Bulk density500 kg/m3
                  Solubility220 g/l
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  RTECSXI7552000
                  Storage class10 - 13 Other liquids and solids
                  WGKWGK 1 slightly hazardous to water
                  Safety Information
                  Product Usage Statements
                  Storage and Shipping Information
                  StorageStore at +2°C to +25°C.
                  Packaging Information
                  Transport Information
                  Supplemental Information
                  Specifications
                  Assay (HPLC, calc. on dried substance)≥ 93.0 %
                  Appearance (color)white
                  Appearance (description)crystalline powder
                  Identity (IR-spectrum)conforms
                  Identity (Cl)passes test
                  Appearance of solution (10 %; water)clear,< colour reference solution Y7
                  pH-value (10 %; water)1.0 - 1.4
                  Chloride (Cl) (calculated on dried substance)7.5 - 7.9 %
                  Free phosphate (PO₄)≤ 1.0 %
                  Sulfate (SO₄)≤ 0.01 %
                  Heavy metals (as Pb)≤ 0.001 %
                  Al (Aluminium) (#)≤ 0.0010 %
                  As (Arsenic)≤ 0.0003 %
                  Ni (Nickel) (#)≤ 0.0002 %
                  Thiamin Monophosphoric Acid Ester Chloride (HPLC)≤ 4.0 %
                  Thiamin Dichloride (HPLC)≤ 0.5 %
                  Dithiamintriphosphate (HPLC)≤ 0.20 %
                  Impurity A (HPLC)≤ 0.1
                  Impurity B (HPLC)≤ 0.1
                  Related substances (HPLC)≤ 1.5 %
                  Loss on drying (130 °C)≤ 1.5 %
                  Endotoxins≤ 12 I.U./g
                  Microbiological testpasses test
                  Colony count (aerobic bacteria (TAMC))≤ 500 CFU/g
                  Colony count (Yeasts and moulds (TYMC))≤ 100 CFU/g
                  Salmonella speciesIn 10g substance not detectable
                  E.coliIn 1g substance not detectable
                  Staphylococcus aureusIn 1g substance not detectable
                  Pseudomonas aeruginosaIn 1g substance not detectable
                  Candida albicansIn 1g substance not detectable
                  Residual solvents (Ph Eur/USP/ICH) class 2 (Methanol)≤ 2.0 %
                  Other residual solvents (Ph Eur/USP/ICH)excluded by manufacturing process
                  Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities).
                  Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (#).
                  Residues of metal or metal reagents acc. to EMEA/CHMP/SWP/ 4446/2000 are not likely to be present.

                  Documentation

                  Elemental Impurities Information

                  Title

                  Cocarboxylase chloride SDS

                  Title

                  Safety Data Sheet (SDS) 

                  Cocarboxylase chloride Certificates of Analysis

                  Product Number PackagingSpecificationLot Number
                  5001120100 Plastic bottlePDF Specification Document
                  5001121000 Plastic bottlePDF Specification Document
                  5001125000 Plastic bottlePDF Specification Document

                  Certificates

                  Title