Durapore 0.45/0.22 µm Hydrophilic Multilayer Filters

Sterilizing grade, hydrophilic Multilayer Durapore 0.45/0.22 µm filters maximize process efficiency by providing high product recovery and extended throughput with low pressure drops.

Overview

Specifications

Ordering Information

Code 0 2-222 O-ring · Code 0, 2-222 O-ring Clear Sorting & Filtering
Catalogue Numbericon Pore Sizeicon Cartridge Nominal Lengthicon
CHGL01TP30.45 / 0.22 µm 10 in. (25 cm) Show Pricing & Availability
CHGL02TP30.45 / 0.22 µm 20 in. (50 cm) Show Pricing & Availability
CHGL03TP30.45 / 0.22 µm 30 in. (75 cm) Show Pricing & Availability

Packaged 3 cartridges per box

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Code 7 2-226 O-ring w/locking-tabs and spear · Code 7, 2-226 O-ring w/locking-tabs and spear Clear Sorting & Filtering
Catalogue Numbericon Pore Sizeicon Cartridge Nominal Lengthicon
CHGL71TP30.45 / 0.22 µm 10 in. (25 cm) Show Pricing & Availability
CHGL72TP30.45 / 0.22 µm 20 in. (50 cm) Show Pricing & Availability
CHGL73TP30.45 / 0.22 µm 30 in. (75 cm) Show Pricing & Availability

Packaged 3 cartridges per box

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    Documentation

    Brochure

    Title
    OptiScale: a small scale screening tool for every application
    Opticap® XL and XLT Capsules Configuration Table

    Data Sheet

    Title
    Durapore® 0.45 μm Hydrophilic Filters
    Hydrophilic Multilayer Durapore® 0.45/0.22μm Filters

    FAQ

    QuestionAnswer
    What are the most common causes of filter clogging (air bubbles, particulates, surface tension, inappropriate filter size etc.)?Trapped bubbles, particulates and improper sizing are all common causes of fitration issues. True filter clogging is caused by particulates. Hard particles will form a cake on the filter surface. This will generally slow the filtration but not necessarily block filtration becuase fluid can flow through the layer of hard particles and then through the filter.

    Deformable particles can compress across the filter pores, forming impermeable barriers to filtration. This type of problem is common with solutions containing proteins or lipids.
    What is the compatibility of Durapore with high pH solutions?The upper recommended pH limit for Durapore membranes is 10. At pH >10, the hydrophilization layer of the membrane may become subject to hydrolysis. The extent of hydrolysis is a function of time, temperature , concentration and time of exposure. Upon exposure to high pH, the hydrophylization layer can swell which could result in a loss of permeability or flux. The hydrolysis of the hydrophilic layer will also lead to increased extractables from the membrane.
    What are Millipore's general recommendations for filtering high pH solutions?For applications involving pH > 10, Millipore recommends the use or our PES membranes Express SHF or Express SHC. For information on these filters :

    Express SHF: http://www.millipore.com/catalogue.nsf/docs/C8873
    Express SHC: http://www.millipore.com/catalogue.nsf/docs/C9146
    How can I differentiate filter plugging due to air bubbles, particulates, surface tension, inappropriate filter size, etc.?Air locking will occur when filtration is initiated without adequate venting or when air bubbles become trapped in fluid lines. Air will pass easily through a dry hydrophillic or hydrophobic filter. However, when a filter is wet and air is applied to a surface, the air will remain until it is manually moved upstream by venting or until the bubble point of the filter is reached. Bubble point is defined as the pressure at which gas displaces liquid for the largest set of filter pores and is able to flow through the pores. Air locking reduces the effective filtration area of the filter and thus reduces the flow rate.

    Surface tension refers to the strong cohesive forces present between molecules at the surface of a liquid. The higher the surface tension, the more force is required to force fluid through the membrane..

    Innapropriate filter size will can cause a filter to plug prematurely. Filter pore size is chosen based on the application. If the application requires a sterile fluid, than a 0.22 micron membrane would be used for standard solutions that have bacterial bioburden. A 0.1 micron filter would be used for applications where mycoplasma is a concern. Where virus contamination is a concern, ultrafiltration would be required. The selection of a filter pore size that is smaller than that required for the application will cause a decrease in filter capacity and an increase in cost.

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    Categories

    Biopharmaceutical Manufacturing > Downstream Processing > Sterile Filtration > Sterile Liquid > Durapore