504378 | EGLU - CAS 170984-72-2 - Calbiochem

504378
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₇H₁₃NO₄170984-72-2
      Description
      Overview

      This product has been discontinued.



      A selective antagonist for group II mGlu receptors (mGlu2 and mGlu3) with low potency (at least 2000- to 3000-fold less potent than LY341495 at mGlu2 receptors expressed in CHO cells). Negligible or no activity at the group III metabotropic and ionotropic glutamate receptors. Extensively used in studies of hippocampal neural plasticity and neurological disorders.

      Catalogue Number504378
      Brand Family Calbiochem®
      Synonyms(2S)-α-Ethylglutamic acid
      References
      ReferencesJane, D., et al. 1996. Neuropharmacology 35, 1029.
      Kimberly, R., 2009. Neurotherapeutics 6, 94.
      Mukherjee, S., et al. 2013. Neuropharmacology 66, 65.
      Cartmell, J., et al. 1998. British J. Pharmacol. 123, 497.
      Odagaki, Y. , et al. 2013. Neurosci. Lett. 539, 22.
      Product Information
      CAS number170984-72-2
      FormWhite solid
      Hill FormulaC₇H₁₃NO₄
      Chemical formulaC₇H₁₃NO₄
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetmGlu2/3
      Primary Target K<sub>i</sub>42 ± 6 →M - 94 ± 3 →M.
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Jane, D., et al. 1996. Neuropharmacology 35, 1029.
      Kimberly, R., 2009. Neurotherapeutics 6, 94.
      Mukherjee, S., et al. 2013. Neuropharmacology 66, 65.
      Cartmell, J., et al. 1998. British J. Pharmacol. 123, 497.
      Odagaki, Y. , et al. 2013. Neurosci. Lett. 539, 22.

      Brochure

      Title
      Pathways and Biomarkers of Glutamatergic Synapse Flyer
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-August-2013 JSW
      Synonyms(2S)-α-Ethylglutamic acid
      DescriptionA selective antagonist for group II mGlu receptors (mGlu2 and mGlu3) with low potency (at least 2000- to 3000-fold less potent than LY341495 at mGlu2 receptors expressed in CHO cells). Negligible or no activity at the group III metabotropic and ionotropic glutamate receptors. Extensively used in studies of hippocampal neural plasticity and neurological disorders.
      FormWhite solid
      CAS number170984-72-2
      Chemical formulaC₇H₁₃NO₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityAqueous basic solutions
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesJane, D., et al. 1996. Neuropharmacology 35, 1029.
      Kimberly, R., 2009. Neurotherapeutics 6, 94.
      Mukherjee, S., et al. 2013. Neuropharmacology 66, 65.
      Cartmell, J., et al. 1998. British J. Pharmacol. 123, 497.
      Odagaki, Y. , et al. 2013. Neurosci. Lett. 539, 22.