01-106 | FGF-2 / basic FGF Protein, Human recombinant

01-106
25 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Key ApplicationsSpeciesSource
      CULTHumanRecombinant DNA expressed in yeast (S. cerevisiae).
      Description
      Catalogue Number01-106
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionFGF-2 / basic FGF Protein, Human recombinant
      References
      Product Information
      PresentationLiquid in PBS, pH 7.4, containing 0.5% BSA and 0.1% CHAPS.
      Applications
      ApplicationThe FGF-2 / basic FGF Protein, Human recombinant is available in a 25 µg format.
      Key Applications
      • Cell Culture
      Biological Information
      SourceRecombinant DNA expressed in yeast (S. cerevisiae).
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.
      Gene Symbol
      • FGF2
      • Prostatropin
      • BFGF
      • prostatropin
      • HBGF-2
      • FGFB
      Purification MethodHeparin-Sepharose™ chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P09038 # The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors.
      SIZE: 155 amino acids; 17254 Da
      SUBUNIT: Monomer. Interacts with CSPG4 and FGFBP1. Found in a complex with FGFBP1, FGF1 and FGF2.
      SIMILARITY: SwissProt: P09038 ## Belongs to the heparin-binding growth factors family.
      MISCELLANEOUS: This protein binds heparin more strongly than does aFGF.
      Stem Cell Type
      • Human Embryonic Stem Cells
      • Neural Stem Cells
      • Epithelial Cells
      • Mesenchymal Stem Cells
      • Pancreatic Stem Cells
      • Induced Pluripotent Stem Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by Biological Activity Assay. Cultures of fetal bovine heart endothelial (FBHE) cells grown for five days in RD medium containing FBS, heparin, and FGF-2 showed more cells than cultures of FBHE cells grown in same medium without FGF-2.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size25 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Certificates of Analysis

      TitleLot Number
      FGF-2 / basic FGF, human recombinant - 16080 16080
      FGF-2 / basic FGF, human recombinant - 16511 16511
      FGF-2 / basic FGF, human recombinant - 17167 17167
      FGF-2 / basic FGF, human recombinant - 17479 17479
      FGF-2 / basic FGF, human recombinant - 17681 17681
      FGF-2 / basic FGF, human recombinant - 18709 18709
      FGF-2 / basic FGF, human recombinant - 18734A 18734A
      FGF-2 / basic FGF, human recombinant - 19363 19363
      FGF-2 / basic FGF, human recombinant - 20516 20516
      FGF-2 / basic FGF, human recombinant - 21404 21404

      References

      Reference overviewApplicationPub Med ID
      Growth factor-induced transcription of GluR1 increases functional AMPA receptor density in glial progenitor cells.
      Chew, L J, et al.
      J. Neurosci., 17: 227-40 (1997)  1997

      Show Abstract
      Cell Culture8987751 8987751
      Antisense inhibition of basic fibroblast growth factor induces apoptosis in vascular smooth muscle cells.
      Fox, J C and Shanley, J R
      J. Biol. Chem., 271: 12578-84 (1996)  1996

      Show Abstract
      Immunoblotting (Western)8647868 8647868
      Differential modulation of basic fibroblast and epidermal growth factor receptor activation by ganglioside GM3 in cultured retinal Müller glia.
      Meuillet, E, et al.
      Glia, 17: 206-16 (1996)  1996

      Show Abstract
      Cell Culture8840162 8840162
      Hematopoietic commitment during embryonic stem cell differentiation in culture.
      Keller, G, et al.
      Mol. Cell. Biol., 13: 473-86 (1993)  1993

      Show Abstract
      Cell Culture8417345 8417345
      Human basic fibroblast growth factor: nucleotide sequence and genomic organization.
      Abraham, J A, et al.
      EMBO J., 5: 2523-8 (1986)  1986

      3780670 3780670

      Data Sheet

      Title
      Reprogramming Cell Fate and Function Novel Strategies for iPSC Generation, Characterization, and Differentiation

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      Categories

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors