530615 | GFRα/RET Signaling Activator, XIB-4035 - CAS 10023-54-8 - Calbiochem

530615
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₂₆H₃₁Cl₂N₃10023-54-8

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      5.30615.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable chlorostyrylquinolinylbutylamino compound that was shown to competitively bind to glial cell line-derived neurotrophic factor (GDNF) family receptor-α1 (GFRα1) and act as an agonist (IC50 = 10.4 µM for 125I-GDNF binding in Neuro-2A cells) and induce autophosphorylation of RET protein. Elicits neurite outgrowth of Neuro-2A cells in a dose-dependent manner. However, some of the recent studies have questioned its agonist nature and have suggested that it acts as a positive modulator of ligand-Induced GFRα/RET signaling and prolongs the GDNF-induced RET phosphorylation. Shown to be effective in treating small fiber neuropathy caused by non-myelinating Schwann cell dysfunction in diabetic murine models leading to improved thermononiception. Does not appear to be toxic up to ~100 µM.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number530615
          Brand Family Calbiochem®
          Synonyms(E)-N⁴-(7-Chloro-2-(2-chlorostyryl)quinolin-4-yl)-N¹,N¹-diethylpentane-1,4-diamine, N-(7-Chloro-2-(2-(2-chlorophenyl)vinyl)-4-quinolinyl)-N-(4-(diethylamino)-1-methylbutyl)amine, XIB 4035
          References
          ReferencesHedstrom, K.L., et al. 2014. Proc. Natl. Acad. Sci. USA 111, 2325.
          Tokugawa, K., et al. 2003. Neurochem. Int. 42, 81.
          Product Information
          CAS number10023-54-8
          FormYellow powder
          Hill FormulaC₂₆H₃₁Cl₂N₃
          Chemical formulaC₂₆H₃₁Cl₂N₃
          ReversibleY
          Applications
          Biological Information
          Primary TargetGFRα1
          Primary Target IC<sub>50</sub>10.4 µM for ¹²⁵I-GDNF binding in Neuro-2A cells
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Hedstrom, K.L., et al. 2014. Proc. Natl. Acad. Sci. USA 111, 2325.
          Tokugawa, K., et al. 2003. Neurochem. Int. 42, 81.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-June-2014 JSW
          Synonyms(E)-N⁴-(7-Chloro-2-(2-chlorostyryl)quinolin-4-yl)-N¹,N¹-diethylpentane-1,4-diamine, N-(7-Chloro-2-(2-(2-chlorophenyl)vinyl)-4-quinolinyl)-N-(4-(diethylamino)-1-methylbutyl)amine, XIB 4035
          DescriptionA cell-permeable chlorostyrylquinolinylbutylamino compound that was shown to competitively bind to glial cell line-derived neurotrophic factor (GDNF) family receptor-α1 (GFRα1) and act as an agonist (IC50 = 10.4 µM for 125I-GDNF binding in Neuro-2A cells) and induce autophosphorylation of RET protein. Elicits neurite outgrowth of Neuro-2A cells in a dose-dependent manner. However, some of the recent studies have questioned its agonist nature and have suggested that it acts as a positive modulator of ligand-Induced GFRα/RET signaling and prolongs the GDNF-induced RET phosphorylation. Shown to be effective in treating small fiber neuropathy caused by non-myelinating Schwann cell dysfunction in diabetic murine models leading to improved thermononiception. Does not appear to be toxic up to ~100 µM.
          FormYellow powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number10023-54-8
          Chemical formulaC₂₆H₃₁Cl₂N₃
          Purity≥97% by HPLC
          SolubilityDMSO (100 mg/ml). Use only fresh DMSO for reconstitution.
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesHedstrom, K.L., et al. 2014. Proc. Natl. Acad. Sci. USA 111, 2325.
          Tokugawa, K., et al. 2003. Neurochem. Int. 42, 81.