12-372 | Histone H4 Peptide, biotin conjugate, residues 2-24

12-372
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Key ApplicationsEntrez Gene NumberUni Prot Number
      IP, APANM_003538.3P62805
      Description
      Catalogue Number12-372
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionHistone H4 Peptide, biotin conjugate, residues 2-24
      References
      Product Information
      PresentationLyophilized powder
      Applications
      ApplicationHistone H4 Peptide, biotin conjugate, residues 2-24 primarily used in Immunoprecipitation and Affinity Precipitation Assays.
      Key Applications
      • Immunoprecipitation
      • Affinity Precipitation Assay
      Biological Information
      Entrez Gene Number
      Entrez Gene SummaryHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
      Gene Symbol
      • HIST1H4A
      • H4/J
      • HIST1H4F
      • HIST1H4L
      • H4FN
      • H4FA
      • H4FH
      • HIST1H4H
      • H4F2
      • H4FM
      • H4/A
      • H4FK
      • H4FG
      • HIST2H4
      • H4FB
      • H4/K
      • HIST1H4I
      • H4/N
      • HIST1H4B
      • H4FE
      • H4/M
      • H4/a
      • HIST1H4E
      • HIST4H4
      • HIST2H4A
      • H4FC
      • H4FI
      • H4/H
      • HIST1H4C
      • H4/G
      • HIST1H4K
      • H4FJ
      • H4FD
      • H4/I
      • H4/B
      • H4/D
      • H4/C
      • HIST1H4J
      • HIST1H4D
      • H4/E
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P62805 # Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
      SIZE: 103 amino acids; 11367 Da
      SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
      SUBCELLULAR LOCATION: Nucleus.
      PTM: Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity). & Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.
      SIMILARITY: SwissProt: P62805 ## Belongs to the histone H4 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by HAT Assay as a substrate in histone acetyl transferase (HAT) and deacetylase assays. For additional information, please refer to HAT and HDAC assay kits (catalog #17-289 and #17-320).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Histone H4 Peptide, biotin conjugate 2884553
      Histone H4 Peptide, biotin conjugate 3085566
      Histone H4 Peptide, biotin conjugate 2933172
      Histone H4 Peptide, biotin conjugate 2955315
      Histone H4 Peptide, biotin conjugate - 2424755 2424755
      Histone H4 Peptide, biotin conjugate - 2450016 2450016
      Histone H4 Peptide, biotin conjugate - 2203612 2203612
      Histone H4 Peptide, biotin conjugate - 2344660 2344660
      Histone H4 Peptide, biotin conjugate - DAM1472198 DAM1472198
      Histone H4 Peptide, biotin conjugate - DAM1724058 DAM1724058

      References

      Reference overviewPub Med ID
      Neonatal exposure to sucralose does not alter biochemical markers of neuronal development or adult behavior.
      Henrik Viberg,Anders Fredriksson
      Nutrition (Burbank, Los Angeles County, Calif.)  27  2011

      Show Abstract
      20116214 20116214
      Catalytic mechanism and function of invariant glutamic acid 173 from the histone acetyltransferase GCN5 transcriptional coactivator.
      Tanner, K G, et al.
      J. Biol. Chem., 274: 18157-60 (1999)  1999

      Show Abstract
      10373413 10373413
      A rapid and sensitive assay for histone acetyl-transferase activity.
      Ait-Si-Ali, S, et al.
      Nucleic Acids Res., 26: 3869-70 (1998)  1998

      9685509 9685509

      Related Products & Applications

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      Categories

      Life Science Research > Proteins and Enzymes > Substrate & Control Proteins > Control Histones