EZHIPI-17K | Human Intact Proinsulin ELISA

EZHIPI-17K
96-well strip plate  
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      Overview

      Replacement Information

      Key Spec Table

      Analytes AvailableSpecies ReactivityKey ApplicationsDetection Methods
      ProinsulinHELISAFluorescent, Colorimetric
      Description
      Catalogue NumberEZHIPI-17K
      DescriptionHuman Intact Proinsulin ELISA
      Background InformationProinsulin, the precursor of insulin and C-peptide, is made by the beta cells of the pancreas. This kit measures only the intact form of human proinsulin
      References
      Product Information
      Detection methodFluorescent Colorimetric
      Precision, %
      • Inter-assay: 3.3–9.0
      • Intra-assay: 0.4–7.7
      Applications
      ApplicationThis Human Intact Proinsulin ELISA is used to measure & quantify Proinsulin levels in Metabolism & Endocrine research.
      Key Applications
      • ELISA
      Application Notes50 μL sample volume 3 hour assay at room temperature
      Biological Information
      Species Reactivity
      • Human
      Analytes Available
      • Proinsulin
      Entrez Gene Number
      Entrez Gene SummaryAfter removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region.
      Gene Symbol
      • INS
      • proinsulin
      • insulin
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01308 # Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
      SIZE: 110 amino acids; 11981 Da
      SUBUNIT: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
      SUBCELLULAR LOCATION: Secreted.
      DISEASE:SwissProt: P01308 # Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730].
      SIMILARITY: SwissProt: P01308 ## Belongs to the insulin family.
      Accuracy
      • 93–97%
      Physicochemical Information
      Sensitivity
      • 0.1 pM
      Linearity of Dilution91–104%
      Standard Curve Range
      • 0.5–100 pM
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size96-well strip plate
      Transport Information
      Supplemental Information
      Specifications