14-1059 | Human Recombinant Hp1α (CBX5)

25 µg  
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      Replacement Information
      Catalogue Number14-1059
      Trade Name
      • Upstate
      DescriptionHuman Recombinant Hp1α (CBX5)
      OverviewFull-length human recombinant Hp1α (CBX5) expressed in E. Coli and purified by Fast Protein Liquid Chromatography (FPLC).
      Background InformationHp1α (CBX5) is a nuclear protein with a calculated molecular weight of 22.5 kDa. This protein is a component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. Hp1α(CBX5) has also been shown to associate with chromosomes during mitosis. This protein can interact with lamin-B receptor (LBR), and this interaction can contribute to the association of the heterochromatin with inner nuclear membrane. It is also involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
      Product Information
      PresentationRecombinant protein in a buffer containing 20mM Tris-Cl pH 7.6, 1mM EDTA, 0.15 M NaCl, 10% glycerol, 0.5mM PMSF and 1mM DTT.
      ApplicationHuman Recombinant Hp1α (CBX5) protein expressed in E. Coli & purified by Fast Protein Liquid Chromatography (FPLC).
      Biological Information
      Concentration0.5 µg/µL
      HostE. coli
      PurityGreater than 98% purity by SDS PAGE
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable at -80ºC for 1 year from date of receipt.
      Packaging Information
      Material Size25 µg
      Transport Information
      Supplemental Information