504042 InSolution™ Doxorubicin, Hydrochloride - CAS 25316-40-9 - Calbiochem

504042
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₂₇H₂₉NO₁₁ · HCl25316-40-9

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      5.04042.0001
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      In Stock 
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          Glass bottle 5 mg
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          Description
          Catalogue Number504042
          Brand Family Calbiochem®
          SynonymsAdriamycin, HCl, 14-Hydroxydaunomycin, HCl
          References
          ReferencesA'Hern, R.P., and Gore, M.E. 1995.J. Clin. Oncol. 13, 726.
          Nooter, K., et al. 1995. Br. J. Cancer 71, 556.
          Noviello, E., et al. 1994. Mutat. Res.. 311, 21.
          Anderson, R.D., et al. 1993. Mutat. Res. 294, 215.
          Hershko, C., et al. 1993. J. Lab. Clin. Med. 122, 245.
          Jongmans, W., et al. 1993. Mutat. Res. 294, 207.
          O'Shaughnessy, J.A., and Cowan, K.H. 1993. J. Am. Med. Assoc. 270, 2089.
          Theyer, G., et al. 1993. J. Urol. 150, 1544.
          Tritton, T.R., and Yee, G. 1982. Science 217, 248.
          Product Information
          CAS number25316-40-9
          FormLiquid
          FormulationA 10 mM (5 mg/862 µL) sterile-filtered solution of Doxorubicin, HCl (Cat. No. 324380) in H₂O.
          Hill FormulaC₂₇H₂₉NO₁₁ · HCl
          Chemical formulaC₂₇H₂₉NO₁₁ · HCl
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Protect from Light Protect from light
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C or -70°C). Aliquots are stable for up to 3 months at -20°C or for up to 6 months at -70°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          A'Hern, R.P., and Gore, M.E. 1995.J. Clin. Oncol. 13, 726.
          Nooter, K., et al. 1995. Br. J. Cancer 71, 556.
          Noviello, E., et al. 1994. Mutat. Res.. 311, 21.
          Anderson, R.D., et al. 1993. Mutat. Res. 294, 215.
          Hershko, C., et al. 1993. J. Lab. Clin. Med. 122, 245.
          Jongmans, W., et al. 1993. Mutat. Res. 294, 207.
          O'Shaughnessy, J.A., and Cowan, K.H. 1993. J. Am. Med. Assoc. 270, 2089.
          Theyer, G., et al. 1993. J. Urol. 150, 1544.
          Tritton, T.R., and Yee, G. 1982. Science 217, 248.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-March-2014 JSW
          SynonymsAdriamycin, HCl, 14-Hydroxydaunomycin, HCl
          DescriptionAn anti-tumor antibiotic and a highly effective myotoxin that inhibits topoisomerase II (IC50 = 100 nM). Binds to nucleic acids, presumably by specific intercalation into the DNA double helix, inhibiting nucleic acid synthesis. Cytotoxicity seems to be due to its ability to intercalate with DNA, interact with plasma membranes, and take part in oxidation-reduction reactions. Induces apoptosis in rhabdomyosarcoma cell lines.
          FormLiquid
          FormulationA 10 mM (5 mg/862 µL) sterile-filtered solution of Doxorubicin, HCl (Cat. No. 324380) in H₂O.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number25316-40-9
          Chemical formulaC₂₇H₂₉NO₁₁ · HCl
          Structure formulaStructure formula
          Purity≥98% by HPLC
          Storage ≤ -70°C
          Protect from light
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C or -70°C). Aliquots are stable for up to 3 months at -20°C or for up to 6 months at -70°C.
          Toxicity Standard Handling
          ReferencesA'Hern, R.P., and Gore, M.E. 1995.J. Clin. Oncol. 13, 726.
          Nooter, K., et al. 1995. Br. J. Cancer 71, 556.
          Noviello, E., et al. 1994. Mutat. Res.. 311, 21.
          Anderson, R.D., et al. 1993. Mutat. Res. 294, 215.
          Hershko, C., et al. 1993. J. Lab. Clin. Med. 122, 245.
          Jongmans, W., et al. 1993. Mutat. Res. 294, 207.
          O'Shaughnessy, J.A., and Cowan, K.H. 1993. J. Am. Med. Assoc. 270, 2089.
          Theyer, G., et al. 1993. J. Urol. 150, 1544.
          Tritton, T.R., and Yee, G. 1982. Science 217, 248.