508315 | InSolution™ KN-93 Phosphate in H₂O - Calbiochem

508315
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₂₆H₂₉ClN₂O₄S • H₃PO₄

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      5.08315.0001
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      Limited AvailabilityLimited Availability
      In Stock 
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          Glass bottle 500 μg
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          Description
          Catalogue Number508315
          Brand Family Calbiochem®
          Synonyms2-(N-(2-Hydroxyethyl))-N-(4-methoxybenzenesulfonyl))amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), Phosphate, (E)-N-(2-(((3-(4-Chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide, Phosphate
          References
          ReferencesTombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
          Chen, C., et al. 1994. Science 266, 291.
          Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
          Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
          Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
          Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.
          Product Information
          FormLiquid
          FormulationA 5 mM (500 µg/167 µL) sterile-filtered solution of KN-93 Phosphate (Cat. No. 422711) in H₂O.
          Hill FormulaC₂₆H₂₉ClN₂O₄S • H₃PO₄
          Chemical formulaC₂₆H₂₉ClN₂O₄S • H₃PO₄
          ReversibleY
          Structure formula Image
          Applications
          Biological Information
          Primary TargetCaM kinase II
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Protect from Light Protect from light
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Tombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
          Chen, C., et al. 1994. Science 266, 291.
          Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
          Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
          Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
          Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-December-2013 JSW
          Synonyms2-(N-(2-Hydroxyethyl))-N-(4-methoxybenzenesulfonyl))amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), Phosphate, (E)-N-(2-(((3-(4-Chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide, Phosphate
          DescriptionA water-soluble form of the CaM kinase II inhibitor KN-93 (Cat. No. 422708). Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets of Langerhans. Has no significant effect on protein kinase A activity. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.
          FormLiquid
          FormulationA 5 mM (500 µg/167 µL) sterile-filtered solution of KN-93 Phosphate (Cat. No. 422711) in H₂O.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₆H₂₉ClN₂O₄S • H₃PO₄
          Structure formula
          Purity≥95% by HPLC
          Storage ≤ -70°C
          Protect from light
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesTombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
          Chen, C., et al. 1994. Science 266, 291.
          Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
          Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
          Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
          Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.