529606 | InSolution™ PP1 Analog II, 1NM-PP1 - CAS 221244-14-0 - Calbiochem

529606
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      Overview

      Replacement Information

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      529606-1MG
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      In Stock 
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          Glass bottle 1 mg
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          Description
          OverviewA cell-permeable and reversible PP1 analog (Cat. No. 529579) that acts as a potent, selective, and ATP-competitive inhibitor of mutant kinases compared to the corresponding wild-type kinase (IC50 = 3.2 nM for T339G, c-Fyn-as1 vs. 1.0 µM for c-Fyn; 4.3 nM for I338G, v-src-as1 vs. 28 µM for v-src; 5 nM for F80G, CDK2-as1 vs. 29 µM for CDK2; 8 nM for F89G, CAMK IIa-as1 vs. 24 µM for CAMKII; 120 nM for T315A, c-Abl-as2 vs. 3.4 µM for c-Abl). Shown to activate mutants of Ire1, a transmembrane kinase.
          Catalogue Number529606
          Brand Family Calbiochem®
          Synonyms4-Amino-1-tert-butyl-3-(1ʹ-naphthylmethyl)pyrazolo[3,4-d]pyrimidine
          References
          ReferencesIra, G., et al. 2004. Nature 431, 1011.
          Papa, F.R., et al. 2003. Science 302, 1533.
          Bishop, A.C., et al. 2000. Nature 407, 395.
          Weiss, E.L., et al. 2000. Nat. Cell Biol. 2, 677.
          Bishop, A.C., et al. 1999. J. Am. Chem. Soc. 121, 627.
          Product Information
          CAS number221244-14-0
          FormLiquid
          FormulationA 10 mM (1 mg/302 µL) solution of PP1 Analog II, 1NM-PP1 (Cat. No. 529581) in DMSO.
          Hill FormulaC₂₀H₂₁N₅
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula Image
          Applications
          Biological Information
          Primary Targetmutant c-Fyn, v-src, Cadk2, CaMKIIa, c-Abl etc.,
          Primary Target IC<sub>50</sub>3.2 nM for T339G, c-Fyn-as1 vs. 1.0 µ
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 36-45

          Wear suitable protective clothing.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Irritant
          Storage ≤ -70°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -70°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          529606

          References

          Reference overview
          Ira, G., et al. 2004. Nature 431, 1011.
          Papa, F.R., et al. 2003. Science 302, 1533.
          Bishop, A.C., et al. 2000. Nature 407, 395.
          Weiss, E.L., et al. 2000. Nat. Cell Biol. 2, 677.
          Bishop, A.C., et al. 1999. J. Am. Chem. Soc. 121, 627.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision01-March-2013 JSW
          Synonyms4-Amino-1-tert-butyl-3-(1ʹ-naphthylmethyl)pyrazolo[3,4-d]pyrimidine
          DescriptionA cell-permeable and reversible PP1 analog (Cat. No. 529579) that acts as a potent, selective, and ATP-competitive inhibitor of mutant kinases compared to the corresponding wild-type kinase (IC50 = 3.2 nM for T339G, c-Fyn-as1 vs. 1.0 µM for c-Fyn; 4.3 nM for I338G, v-src-as1 vs. 28 µM for v-src; 5 nM for F80G, CDK2-as1 vs. 29 µM for CDK2; 8 nM for F89G, CAMK IIa-as1 vs. 24 µM for CAMKII; 120 nM for T315A, c-Abl-as2 vs. 3.4 µM for c-Abl). Shown to activate mutants of Ire1, a transmembrane kinase.
          FormLiquid
          FormulationA 10 mM (1 mg/302 µL) solution of PP1 Analog II, 1NM-PP1 (Cat. No. 529581) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number221244-14-0
          Structure formula
          Purity≥95% by HPLC
          Storage ≤ -70°C
          Hygroscopic
          Protect from light
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -70°C.
          Toxicity Irritant
          ReferencesIra, G., et al. 2004. Nature 431, 1011.
          Papa, F.R., et al. 2003. Science 302, 1533.
          Bishop, A.C., et al. 2000. Nature 407, 395.
          Weiss, E.L., et al. 2000. Nat. Cell Biol. 2, 677.
          Bishop, A.C., et al. 1999. J. Am. Chem. Soc. 121, 627.