508319 | InSolution™ TNP-ATP - Calbiochem

508319
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₁₆H₁₂N₈O₁₉P₃Na₄
      Description
      Overview

      This product has been discontinued.



      A highly potent, non-competitive antagonist of purinergic P2X3 receptor (IC50 = 900 pM) and blocks a,b-MeATP evoked responses in rat mesenteric artery smooth muscle cells. Reportedly binds to an allosteric site on the large extracellular region of the receptor. Also, blocks P2X1 and P2X2/3 receptors at higher concentration (IC50 = 6 and 7 nM, respectively). Does not affect P2X2, P2X4, or P2X7 receptors in any significant manner (IC50 = 2.0, 15.2, and 30 µM, respectively). Shown to reduce resiniferatoxin- induced neuropathic pain in a dose-dependent manner. Also used as a fluorescent probe for ATP binding.

      Catalogue Number508319
      Brand Family Calbiochem®
      Synonyms2ʹ,3ʹ-O-(2,4,6-Trinitrophenyl) adenosine 5ʹ-triphosphate Sodium Salt, Purinergic P2X3 Receptor Antagonist, TNP-ATP, Purinergic Receptor Antagonist, TNP-ATP, Fluorescent ATP Analog, TNP-ATP
      References
      ReferencesHsieh, Y.L., et al. 2012. Exp. Neurol. 235, 316.
      Virginio, C., et al. 1998. Mol. Pharmacol. 53, 969.
      Hiratsuka, T. et, al. 1975. J. Biochem. 78, 1135.
      Product Information
      FormRed liquid
      Hill Formula C₁₆H₁₂N₈O₁₉P₃Na₄
      Chemical formulaC₁₆H₁₂N₈O₁₉P₃Na₄
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary Target IC<sub>50</sub>900 pM
      Purity≥90% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Hsieh, Y.L., et al. 2012. Exp. Neurol. 235, 316.
      Virginio, C., et al. 1998. Mol. Pharmacol. 53, 969.
      Hiratsuka, T. et, al. 1975. J. Biochem. 78, 1135.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-October-2013 JSW
      Synonyms2ʹ,3ʹ-O-(2,4,6-Trinitrophenyl) adenosine 5ʹ-triphosphate Sodium Salt, Purinergic P2X3 Receptor Antagonist, TNP-ATP, Purinergic Receptor Antagonist, TNP-ATP, Fluorescent ATP Analog, TNP-ATP
      DescriptionA highly potent, non-competitive antagonist of purinergic P2X3 receptor (IC50 = 900 pM) and blocks a,b-MeATP evoked responses in rat mesenteric artery smooth muscle cells. Reportedly binds to an allosteric site on the large extracellular region of the receptor. Also, blocks P2X1 and P2X2/3 receptors at higher concentration (IC50 = 6 and 7 nM, respectively). Does not affect P2X2, P2X4, or P2X7 receptors in any significant manner (IC50 = 2.0, 15.2, and 30 µM, respectively). Shown to reduce resiniferatoxin- induced neuropathic pain in a dose-dependent manner. Also used as a fluorescent probe for ATP binding.
      FormRed liquid
      Chemical formulaC₁₆H₁₂N₈O₁₉P₃Na₄
      Structure formulaStructure formula
      Purity≥90% by HPLC
      Solubility10 mM Phosphate Buffer
      Storage ≤ -70°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesHsieh, Y.L., et al. 2012. Exp. Neurol. 235, 316.
      Virginio, C., et al. 1998. Mol. Pharmacol. 53, 969.
      Hiratsuka, T. et, al. 1975. J. Biochem. 78, 1135.