504462 | InSolution™ Wnt Antagonist I, IWR-1-endo - CAS 1127442-82-3 - Calbiochem

504462
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₂₅H₁₉N₃O₃1127442-82-3

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      5.04462.0001
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          Glass bottle 5 mg
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          Description
          Catalogue Number504462
          Brand Family Calbiochem®
          SynonymsInhibitor of Wnt Response-1, TNKS1/2 Inhibitor II, Tankyrase1/2 Inhibitor II, Wnt Pathway Inhibitor I
          References
          ReferencesWang, H., et al. 2011. ACS Chem. Biol. 6, 192.
          Chen, B., et al. 2009. Nature Chem. Biol. 5, 100.
          Huang, S.M., et al. 2009. Nature 461, 614.
          Product Information
          CAS number1127442-82-3
          FormLiquid
          FormulationA 25 mM (5 mg/489 µL) solution of Wnt Antagonist I, IWR-1-endo (Cat. No. 681669) in DMSO.
          Hill FormulaC₂₅H₁₉N₃O₃
          Chemical formulaC₂₅H₁₉N₃O₃
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula Image
          Applications
          Biological Information
          Primary TargetAxin
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26-45

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Irritant
          Storage ≤ -70°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Wang, H., et al. 2011. ACS Chem. Biol. 6, 192.
          Chen, B., et al. 2009. Nature Chem. Biol. 5, 100.
          Huang, S.M., et al. 2009. Nature 461, 614.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-June-2013 JSW
          SynonymsInhibitor of Wnt Response-1, TNKS1/2 Inhibitor II, Tankyrase1/2 Inhibitor II, Wnt Pathway Inhibitor I
          DescriptionA cell-permeable p-imidobenzamidoquinoline, endo-diastereomer that is shown to inhibit the activity of TNKS1/PARP5a and TNKS2/PARP5b in in vitro auto-PARsylation assays (IC50 = 131 and 56 nM, respectively) and effectively suppress Wnt-stimulated transcription activity in L-Wnt-STF-based reporter assays (IC50 = 180 nM), while exhibiting little activity against PARP1 or PARP2 (IC50 >18.75 µM). Although both IWR-1-endo and XAV939 (Tankyrase1/2 Inhibitor; Cat. No. 575545) act as reversible Wnt pathway inhibitors and exhibit similar pharmacological effects both in vitro and in vivo, IWR-1-endo exerts its effect via interaction with Axin, while XAV939 binds TNKS directly.
          FormLiquid
          FormulationA 25 mM (5 mg/489 µL) solution of Wnt Antagonist I, IWR-1-endo (Cat. No. 681669) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1127442-82-3
          Chemical formulaC₂₅H₁₉N₃O₃
          Structure formula
          Purity≥95% by HPLC
          Storage ≤ -70°C
          Hygroscopic
          Protect from light
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
          Toxicity Irritant
          ReferencesWang, H., et al. 2011. ACS Chem. Biol. 6, 192.
          Chen, B., et al. 2009. Nature Chem. Biol. 5, 100.
          Huang, S.M., et al. 2009. Nature 461, 614.