508228 | L- Buthionine Sulfoximine - CAS 83730-53-4 - Calbiochem

508228
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₈H₁₈N₂O₃S83730-53-4

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      5.08228.0001
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          Glass bottle 100 mg
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          Description
          OverviewA cell-permeable, sulfoximine based compound that acts a potent, fast acting, irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. Closely resembles the structure of g-glutamylphosphate cysteine adduct. The inhibition follows the first order kinetics with t1/2 = ~ 11 sec at saturating inhibitor concentration. Does not affect the activity of glutamine synthetase. Shown to improve the outcome of chemotherapy by lowering the levels of glutathione in cancer cells (IC50 = 1.9, 8.6, and 29 µM in melanoma, breast, and ovarian tumor cells, respectively).
          Catalogue Number508228
          Brand Family Calbiochem®
          References
          ReferencesFruehauf, J.P., et al. 1997. Pigment Cell Res. 10, 236.
          OʹDwyer, P.J., et al. 1996. J. Clin. Oncol.14, 249.
          Griffith, O. W., 1982. J. Biol. Chem. 257, 13704.
          Griffith, O. W., et al. 1979. J. Biol. Chem. 254, 7558.
          Product Information
          CAS number83730-53-4
          FormWhite powder
          Hill FormulaC₈H₁₈N₂O₃S
          Chemical formulaC₈H₁₈N₂O₃S
          Structure formula Image
          Applications
          Biological Information
          Primary Targetgamma-glutamylcysteine synthetase
          Purity≥97% by TLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Fruehauf, J.P., et al. 1997. Pigment Cell Res. 10, 236.
          OʹDwyer, P.J., et al. 1996. J. Clin. Oncol.14, 249.
          Griffith, O. W., 1982. J. Biol. Chem. 257, 13704.
          Griffith, O. W., et al. 1979. J. Biol. Chem. 254, 7558.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-October-2013 JSW
          DescriptionA cell-permeable, sulfoximine based compound that acts a potent, fast acting, irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. Closely resembles the structure of g-glutamylphosphate cysteine adduct. The inhibition follows the first order kinetics with t1/2 = ~ 11 sec at saturating inhibitor concentration. Does not affect the activity of glutamine synthetase. Shown to improve the outcome of chemotherapy by lowering the levels of glutathione in cancer cells (IC50 = 1.9, 8.6, and 29 µM in melanoma, breast, and ovarian tumor cells, respectively).
          FormWhite powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number83730-53-4
          Chemical formulaC₈H₁₈N₂O₃S
          Structure formula
          Purity≥97% by TLC
          SolubilityH₂O (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesFruehauf, J.P., et al. 1997. Pigment Cell Res. 10, 236.
          OʹDwyer, P.J., et al. 1996. J. Clin. Oncol.14, 249.
          Griffith, O. W., 1982. J. Biol. Chem. 257, 13704.
          Griffith, O. W., et al. 1979. J. Biol. Chem. 254, 7558.