524615 | L-α-Phosphatidylinositol-3,4,5-trisphosphate, Dipalmitoyl-, Heptaammonium Salt - Calbiochem

524615
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₄₁H₇₅O₂₂P₄ · 7NH₄
      Description
      Overview

      This product has been discontinued.



      Activates Ca2+-insensitive PKC isozymes δ, ε, and η. Binds to the general receptor for phosphoinositide-1 (GRP1) protein through a plekstrin homology (PH) domain. Also reported to increase the motility of NIH/3T3 cells and produce actin reorganization and membrane ruffling.

      Catalogue Number524615
      Brand Family Calbiochem®
      SynonymsPI-3,4,5-P₃, 7NH₄, PIP₃, Dipalmitoyl-
      References
      ReferencesDerman, M.P., et al. 1997. J. Biol. Chem. 272, 6465.
      Klarlund, J.K., et al. 1997. Science 275, 1927.
      Ireton, K., et al. 1996. Science 274, 780.
      Toker, A., et al. 1994. J. Biol. Chem. 269, 32358.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₄₁H₇₅O₂₂P₄ · 7NH₄
      Chemical formulaC₄₁H₇₅O₂₂P₄ · 7NH₄
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetCa2+-insensitive PKC isozymes δ, ε, and η
      Purity≥98% by NMR
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      524615

      References

      Reference overview
      Derman, M.P., et al. 1997. J. Biol. Chem. 272, 6465.
      Klarlund, J.K., et al. 1997. Science 275, 1927.
      Ireton, K., et al. 1996. Science 274, 780.
      Toker, A., et al. 1994. J. Biol. Chem. 269, 32358.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-August-2008 RFH
      SynonymsPI-3,4,5-P₃, 7NH₄, PIP₃, Dipalmitoyl-
      DescriptionSynthetic. Activates Ca2+-insensitive PKC isotypes δ, ε, and η. Binds to the GRP1 protein through a plekstrin homology (PH) domain. Also reported to increase the motility of NIH 3T3 cells and produce actin reorganization and membrane ruffling.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₄₁H₇₅O₂₂P₄ · 7NH₄
      Structure formulaStructure formula
      Purity≥98% by NMR
      SolubilityDMSO (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Irritant
      ReferencesDerman, M.P., et al. 1997. J. Biol. Chem. 272, 6465.
      Klarlund, J.K., et al. 1997. Science 275, 1927.
      Ireton, K., et al. 1996. Science 274, 780.
      Toker, A., et al. 1994. J. Biol. Chem. 269, 32358.