508438 | Lamellipodial Growth Promoter, C8N6 BPA Polyamine - Calbiochem

508438
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₂₀H₄₈N₆·6HCl

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      5.08438.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable, fast acting, branched polyamine (C8N6) that specifically induces the growth of actin-enriched lamellipodia within minutes (at ~10-100 µM) without the need for serum cofactors . Its effects are more pronounced on the edges of cells that exhibit lamellipodial activity before any treatment. Enhances nucleation by capping protein and thereby facilitates the initiation of filament branching at the lamellipodium tip. Does not affect actin polymerization in cells pre-treated with depolymerizing agents. Does not affect the survival or death of tumor cells even at higher concentration (1 mM). The assembly of actin appears to be more distinct at physiological ionic concentrations.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number508438
          Brand Family Calbiochem®
          SynonymsActin Regulator, C8N6 BPA polyamine, Lamellipodial Enhancer, C8N6 BPA polyamine
          References
          ReferencesNedeva, I., et al. 2013. Nat. Commun. 4, 2165.
          Product Information
          FormOff-white solid
          Hill FormulaC₂₀H₄₈N₆·6HCl
          Chemical formulaC₂₀H₄₈N₆·6HCl
          Applications
          Biological Information
          Purity≥98% by NMR
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Nedeva, I., et al. 2013. Nat. Commun. 4, 2165.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-June-2015 JSW
          SynonymsActin Regulator, C8N6 BPA polyamine, Lamellipodial Enhancer, C8N6 BPA polyamine
          DescriptionA cell-permeable, fast acting, branched polyamine (C8N6) that specifically induces the growth of actin-enriched lamellipodia within minutes (at ~ 10-100 µM) without the need for serum cofactors . Its effects are more pronounced on the edges of cells that exhibit lamellipodial activity before any treatment. Enhances nucleation by capping protein and thereby facilitates the initiation of filament branching at the lamellipodium tip. Does not affect actin polymerization in cells pre-treated with depolymerizing agents. Does not affect the survival or death of tumor cells even at higher concentration (1 mM). The assembly of actin appears to be more distinct at physiological ionic concentrations. The Cy3 conjugated version is also available (Cat. No. xxxx?)
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₀H₄₈N₆·6HCl
          Purity≥98% by NMR
          SolubilityDMSO (50 mg/ml) or H₂O (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesNedeva, I., et al. 2013. Nat. Commun. 4, 2165.