437622 | Lipocortin-II, His•Tag®, Human, Recombinant, E. coli

437622
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      Overview

      Replacement Information

      Key Spec Table

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      437622-50UG
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      In Stock 
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          Plastic ampoule 50 μg
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          Description
          OverviewFull-length, recombinant, human, lipocortin-II fused at the N-terminus to His•Tag® and S•Tag™ sequences and expressed in E. coli. This preparation is qualified for use as a substrate for protein tyrosine kinases in in vitro assays. Lipocortin-II is a Ca2+-binding protein whose affinity for calcium is increased by anionic phospholipids. It binds two calcium ions with high-affinity and crosslinks plasma membrane phospholipids with actin and the cytoskeleton and is involved with exocytosis. It is known to be phosphorylated at Tyr23 by Src and at Ser25 by PKC. It is also a substrate for a variety of other protein tyrosine kinases.
          Catalogue Number437622
          Brand Family Calbiochem®
          SynonymsAnnexin-II, Human, Recombinant, Calpactin-I, Human, Recombinant, Lipocortin-II, Human, Recombinant
          Application Data
          References
          ReferencesDeora, A.B., et al. 2004. J. Biol. Chem. 279, 43411.
          Lennon, G., et al. 1996. Genomics 33, 151.
          Barton, G. J., et al. 1991. Eur. J. Biochem. 198, 749.
          Product Information
          FormLiquid
          FormulationIn PBS, 0.2% Protease Inhibitor Cocktail Set VII (Cat. No. 539138).
          Applications
          Biological Information
          Purity≥90% by SDS-PAGE
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Irritant
          Storage ≤ -70°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          437622

          References

          Reference overview
          Deora, A.B., et al. 2004. J. Biol. Chem. 279, 43411.
          Lennon, G., et al. 1996. Genomics 33, 151.
          Barton, G. J., et al. 1991. Eur. J. Biochem. 198, 749.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-August-2008 RFH
          SynonymsAnnexin-II, Human, Recombinant, Calpactin-I, Human, Recombinant, Lipocortin-II, Human, Recombinant
          Application Data
          DescriptionFull-length, recombinant, human, lipocortin-II fused at the N-terminus to His•Tag® and S•Tag™ sequences and expressed in E. coli. This preparation is qualified for use as a substrate for protein tyrosine kinases in in vitro assays. Lipocortin-II is a Ca2+-binding protein whose affinity for calcium is increased by anionic phospholipids. It binds two calcium ions with high-affinity and crosslinks plasma membrane phospholipids with actin and the cytoskeleton and is involved with exocytosis. It is known to be phosphorylated at Tyr23 by Src and at Ser25 by PKC. It is also a substrate for a variety of other protein tyrosine kinases.
          FormLiquid
          FormulationIn PBS, 0.2% Protease Inhibitor Cocktail Set VII (Cat. No. 539138).
          Concentration Label Please refer to vial label for lot-specific concentration
          Purity≥90% by SDS-PAGE
          Storage ≤ -70°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Toxicity Irritant
          ReferencesDeora, A.B., et al. 2004. J. Biol. Chem. 279, 43411.
          Lennon, G., et al. 1996. Genomics 33, 151.
          Barton, G. J., et al. 1991. Eur. J. Biochem. 198, 749.