Key Spec Table
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|438075-10MG||Glass bottle||10 mg||
|Overview||A cell-permeable purine compound that acts as a reversible and ATP-competitive dual inhibitor of CKIα and CKIδ activities (IC50 = 5.6 and 8.8 µM) with moderate selectivity over Cdk7 and Erk2 (IC50 = 29 and 52 µM). Shown to block CKIα/δ-mediated phosphorylation of PER1, a clock protein, (IC50 ~ 9 µM) and repress PER1 proteasomal degradation, and lengthen the circadian period in U2OS cells (by ~ 13 hrs at 10 µM) much more effectively than Casein Kinase I Inhibitor, D4476 (Cat. No. 218696) and IC261 (Cat. No. 400090) and in larval zebra fish.|
|Synonyms||9-Isopropyl-N-(3-(trifluoromethyl)benzyl)-9H-purin-6-amine, Casein Kinase I Inhibitor VII|
|References||Hirota, T., et al. 2010. PLoS Biol. 8, e1000559.|
|Structure formula Image|
|Purity||≥99% by HPLC|
|Safety Information according to GHS|
|R Phrase||R: 22
Harmful if swallowed.
|S Phrase||S: 22-36/37/39
Do not breathe dust.
Wear suitable protective clothing, gloves and eye/face protection.
|Product Usage Statements|
|Packaged under inert gas||Packaged under inert gas|
|Hirota, T., et al. 2010. PLoS Biol. 8, e1000559.|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.