508162 | Loperamide Hydrochloride - CAS 34552-83-5 - Calbiochem

508162
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₂₉H₃₃ClN₂O₂·HCl34552-83-5

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      5.08162.0001
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          Glass bottle 1 gm
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          Description
          OverviewA very potent and highly selective peripheral resctricted µ-opioid receptor agonist (Ki = 2 nM). Often used as an antidiarrheal, antipruritic, and antihyperalgesic agent. In addition, shown to improve defective post-receptor insulin signaling in skeletal muscle cells and enhance insulin sensitivity in rats.
          Catalogue Number508162
          Brand Family Calbiochem®
          Synonymsµ-Opioid Receptor Agonist, Loperamide Hydrochloride, Imodium
          References
          ReferencesCheng, K., et al. 2013. Pharmaco. Ther. 139, 334.
          Di Bosco, M., et al. 2008. Chem. Biol. Drug Des. 71, 328.
          DeHaven-Hudkins, D., et al. 1999. J. Pharmacol. Exp. Ther. 289, 494.
          Mackerer, C., et al. 1976. J. Pharmacol. Exp. Ther. 199, 131.
          Product Information
          CAS number34552-83-5
          FormWhite solid
          Hill FormulaC₂₉H₃₃ClN₂O₂·HCl
          Chemical formulaC₂₉H₃₃ClN₂O₂·HCl
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetu opioid receptor
          Primary Target K<sub>i</sub>2 nM
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 25

          Toxic if swallowed.
          S PhraseS: 36/37/39-46

          Wear suitable protective clothing, gloves and eye/face protection.
          If swallowed, seek medical advice immediately and show this container or label.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Cheng, K., et al. 2013. Pharmaco. Ther. 139, 334.
          Di Bosco, M., et al. 2008. Chem. Biol. Drug Des. 71, 328.
          DeHaven-Hudkins, D., et al. 1999. J. Pharmacol. Exp. Ther. 289, 494.
          Mackerer, C., et al. 1976. J. Pharmacol. Exp. Ther. 199, 131.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-October-2013 JSW
          Synonymsµ-Opioid Receptor Agonist, Loperamide Hydrochloride, Imodium
          DescriptionA very potent and highly selective peripheral resctricted µ-opioid receptor agonist (Ki = 2 nM). Often used as an antidiarrheal, antipruritic, and antihyperalgesic agent. In addition, shown to improve defective post-receptor insulin signaling in skeletal muscle cells and enhance insulin sensitivity in rats.
          FormWhite solid
          CAS number34552-83-5
          Chemical formulaC₂₉H₃₃ClN₂O₂·HCl
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (50 mM) or Ethanol (50 mM). Warming is required for complete solubilization in ethanol.
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Toxic
          ReferencesCheng, K., et al. 2013. Pharmaco. Ther. 139, 334.
          Di Bosco, M., et al. 2008. Chem. Biol. Drug Des. 71, 328.
          DeHaven-Hudkins, D., et al. 1999. J. Pharmacol. Exp. Ther. 289, 494.
          Mackerer, C., et al. 1976. J. Pharmacol. Exp. Ther. 199, 131.