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MABN630 Anti-SDHA Antibody, clone 7H11.2

Anti-SDHA, clone 7H11.2 is an antibody against SDHA for use in WB, IH.

Anti-SDHA Antibody, clone 7H11.2 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurodegenerative Diseases Gene Symbol: SDHA, SDH2, SDHF UniProt Number: P31040
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MABN630
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN630
      DescriptionAnti-SDHA Antibody, clone 7H11.2
      Alternate Names
      • Flavoprotein subunit of complex II
      • Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
      Background InformationSDHA, also known as Succinate dehydrogenase flavoprotein-mitochondrial subunit, or Flavoprotein subunit of complex II (Fp), and encoded by the gene symbol SDHA/ SDH2/ SDHF, is a member of the FAD-dependent oxidoreductase 2 family and the FRD/SDH subfamily. Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) is involved in the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Recent studies have indicated that SDHA may act as a tumor suppressor. SDHA is composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. SDHA interacts with SDHAF2/SDH5 in the process required for FAD attachment. Additionally, FDHA has been shown to interact with TRAP1. Mutations in the SDHA gene have been associated with Mitochondrial complex II deficiency (MT-C2D), a disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations. Additionally, mutations in the SDHA gene have been implied in Leigh syndrome or Kearns-Sayre syndrome, Cardiomyopathy dilated 1GG (CMD1GG), and Paragangliomas 5 (PGL5).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-SDHA, clone 7H11.2 is an antibody against SDHA for use in WB, IH.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern Blotting Analysis: A 0.5 µg/mL dilution from a representative lot detected SDHA in 10 µg of C2C12 and HeLa cell lysates.
      Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected SDHA in human cerebral cortex and human cardiac myocytes tissues.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to the C-terminus of Human SDHA.
      EpitopeImmunogen is near the C-terminal.
      Clone7H11.2
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SDHA
      • SDH2
      • SDHF
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~68 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Human brain tissue lysate.

      Western Blotting Analysis: A 0.5 µg/mL diultion of this antibody detected SDHA in 10 µg of Human brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABN630 04055977113662