444149 | MDM2 Antagonist III

444149
  
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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.

      Please refer to our complete listing of MDM inhibitors and antagonists for possible alternatives. Please read the alternative product documentation carefully and contact technical service if you need additional information.





      A cell-permeable isoindolinone compound that binds to MDM2 and disrupts MDM2-p53 interaction (IC50 = 15.9 µM). Shown to upregulate p53-dependent luciferase activity and cellular levels of MDM2 and p21 in SJSA cells.
      Catalogue Number444149
      Brand Family Calbiochem®
      Synonyms2-Benzyl-3-(4-chlorophenyl)-3-(3-hydroxypropoxy)-2,3-dihydroisoindol-1-one, MDM2 Inhibitor III
      References
      ReferencesHardcastle, I.R., et al. 2006. J. Med. Chem. 49, 6209. Hardcastle, I.R., et al. 2006. Bioorg. Med. Chem. Lett. 15, 1515.
      Product Information
      FormWhite solid
      Hill FormulaC₂₄H₂₂ClNO₃
      Chemical formulaC₂₄H₂₂ClNO₃
      Structure formula Image
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Certificates of Analysis

      TitleLot Number
      444149

      References

      Reference overview
      Hardcastle, I.R., et al. 2006. J. Med. Chem. 49, 6209. Hardcastle, I.R., et al. 2006. Bioorg. Med. Chem. Lett. 15, 1515.

      Brochure

      Title
      Interactive Pathway Calendar
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-August-2008 RFH
      Synonyms2-Benzyl-3-(4-chlorophenyl)-3-(3-hydroxypropoxy)-2,3-dihydroisoindol-1-one, MDM2 Inhibitor III
      DescriptionA cell-permeable isoindolinone compound that binds to MDM2 and disrupts MDM2-p53 interaction (IC50 = 15.9 µM). Shown to upregulate p53-dependent luciferase activity and cellular levels of MDM2 and p21 in SJSA cells.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₄H₂₂ClNO₃
      Structure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml) or Ethanol (10 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesHardcastle, I.R., et al. 2006. J. Med. Chem. 49, 6209. Hardcastle, I.R., et al. 2006. Bioorg. Med. Chem. Lett. 15, 1515.