TGFBMAG-64K-01 | MILLIPLEX MAP TGFß1 Magnetic Bead Single Plex Kit - Immunology Multiplex Assay

TGFBMAG-64K-01
96-well plate  
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      Overview

      Replacement Information

      Key Spec Table

      Analytes AvailableSpecies ReactivityKey ApplicationsDetection Methods
      TGF-β1H, M, R, NhP, Ca, Fe, PoMplexLuminex xMAP
      Description
      Catalogue NumberTGFBMAG-64K-01
      Trade Name
      • MILLIPLEX
      DescriptionMILLIPLEX MAP TGFß1 Magnetic Bead Single Plex Kit - Immunology Multiplex Assay
      Background InformationThe transforming growth factor beta (TGFβ) system, a superfamily of cytokines as well as signaling pathways, is highly conserved throughout the animal kingdom. TGFβ functions in immune cell development, angiogenesis, wound healing and embryonic development, bone development and plays a critical role in immune response, heart disease, and cancer. In its normal state TGFβ is one of the few classes of proteins able to inhibit cell growth by halting mitosis at the G1 state, inducing cell differentiation or apoptosis. However, during oncogenesis mutations in the TGFβ signaling pathway result in tumor cell resistance to the effects of normally functioning TGFβ, causing proliferation without regulation. Initial research suggests that VE-cadherin may enhance the mutated TGFβ signaling pathway.
      References
      Product Information
      Detection methodLuminex xMAP
      ConfigurationSingle Plex
      Precision, %
      • Inter-assay: < 10
      • Intra-assay: < 10
      Panel TypeMAGNETIC Cytokines/Chemokines
      Applications
      ApplicationThis MILLIPLEX MAP TGF ß1 (Transforming Growth Factor Beta) - Single Plex is an Immunology Multiplex Assay used for the simultaneous quantification of theTGF-β1 biomarker in the following species: Mouse/Human/Rat/Pig/Horse/Rabbit/Guinea Pig/Hamster.
      Key Applications
      • Multiplexing
      Application Notes• This assay requires an acidification sample treatment.
      • This is a 2-hour or overnight incubation assay.
      • This assay requires 25 μL of a 1:30 dilution after treatment of serum and plasma samples.
      Biological Information
      SpecificityIn addition to human TGFβ1, the assay can detect TGFβ1 in serum of the following; horse, rabbit, mouse, rat, mini pig, canine, hamster, guinea pig, rhesus monkey and cynomolgous monkey. However, the exact amount of cross reactivity has not been determined.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      • Non-human Primate
      • Canine
      • Feline
      • Pig
      Analytes Available
      • TGF-β1
      Assay PanelEverything you need in a single kit.
      Accuracy
      • 100%
      Physicochemical Information
      Sensitivity
      • 12 pg/mL
      Standard Curve Range
      • 9.8 - 2,500 pg/mL
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsRecommended storage for kit components is 2 - 8°C.
      Packaging Information
      Material Size96-well plate
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Protocols

      Title
      Protocol: TGFβ 1,2,3 Magnetic Bead Kit

      SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overviewPub Med ID
      Blockade of A2B adenosine receptor reduces left ventricular dysfunction and ventricular arrhythmias 1 week after myocardial infarction in the rat model.
      Zhang, H; Zhong, H; Everett, TH; Wilson, E; Chang, R; Zeng, D; Belardinelli, L; Olgin, JE
      Heart rhythm : the official journal of the Heart Rhythm Society  11  101-9  2014

      Show Abstract
      24120874 24120874
      Low-dose gemcitabine depletes regulatory T cells and improves survival in the orthotopic Panc02 model of pancreatic cancer.
      Shevchenko, I; Karakhanova, S; Soltek, S; Link, J; Bayry, J; Werner, J; Umansky, V; Bazhin, AV
      International journal of cancer. Journal international du cancer  133  98-107  2013

      Show Abstract
      23233419 23233419

      Brochure

      Title
      Analyte Quarterly Vol. 2 2017
      Custom Immunoassay Menu of Services
      The Power of Biomarker Analysis

      Technical Info

      Title
      96 well Template 2 Up
      96 well Template Single
      Quality Control Ranges: Milliplex TGF-b1 Single Plex

      Data Sheet

      Title
      Full Service Custom-built Assays

      Posters

      Title
      MILLIPLEX MAP: The Immunology of Cancer
      Biomarkers of the tumor mIcroenvironment
      Cancer & Metastasis Signaling Pathways
      MILLIPLEX® MAP Cell Signaling Wall Chart (MM)
      Multiplex Assays of Fifteen Human Complement Factors

      Related Products & Applications

      Alternative Format

      Catalogue Number Description  
      TGFBMAG-64K-03 MILLIPLEX MAP TGFß Magnetic Bead 3 Plex Kit - Immunology Multiplex Assay Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Immunoassays > Multiplexed Immunoassays > Milliplex MAP Assay Products > Premixed Kits
      Life Science Research > Protein Detection and Quantification > Immunoassays > Multiplexed Immunoassays > Milliplex MAP Assay Products > Premixed Kits