475730 | MRP1 Inhibitor II, Reversan - Calbiochem

475730
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₂₆H₂₇N₅O₂

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      475730-10MG
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      In Stock 
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          10 mg
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          Description
          OverviewA cell-permeable pyrazolopyrimidine that selectively inhibits MRP1. It is shown to increase the efficacy of vincristine and etopiside by 10- to 15-fold and 7- to 10-fold, respectively, over either of these two MRP1 substrate drugs alone in murine models of neuroblastoma (syngenic and human xenografts). As opposed to the majority of inhibitors of multidrug transporters, it is demonstrated that Reversan was not toxic by itself nor did it increase the toxicity of chemotherapeutic drug exposure in mice. Therefore, Reversan represents a new class of nontoxic MRP1 inhibitor, which may be a useful research tool for the study of neuroblastoma and other MRP1-overexpressing drug-refractory tumors.
          Catalogue Number475730
          Brand Family Calbiochem®
          SynonymsMultidrug Resistance Protein 1 Inhibitor, Reversan
          References
          ReferencesBurkhart, C.A., et al. 2009. Cancer Res. 69, 6573.
          Product Information
          FormPale yellow solid
          Hill FormulaC₂₆H₂₇N₅O₂
          Chemical formulaC₂₆H₂₇N₅O₂
          Structure formula Image
          Applications
          Biological Information
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          475730

          References

          Reference overview
          Burkhart, C.A., et al. 2009. Cancer Res. 69, 6573.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-December-2010 RFH
          SynonymsMultidrug Resistance Protein 1 Inhibitor, Reversan
          DescriptionA cell-permeable pyrazolopyrimidine that selectively inhibits MRP1. It is shown to increase the efficacy of vincristine and etopiside by 10- to 15-fold and 7- to 10-fold, respectively, over either of these two MRP1 substrate drugs alone in murine models of neuroblastoma (syngenic and human xenografts). As opposed to the majority of inhibitors of multidrug transporters, it is demonstrated that Reversan was not toxic by itself nor did it increase the toxicity of chemotherapeutic drug exposure in mice. Therefore, Reversan represents a new class of nontoxic MRP1 inhibitor, which may be a useful research tool for the study of neuroblastoma and other MRP1-overexpressing drug-refractory tumors.
          FormPale yellow solid
          Chemical formulaC₂₆H₂₇N₅O₂
          Structure formula
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesBurkhart, C.A., et al. 2009. Cancer Res. 69, 6573.