444324 | Margatoxin, Recombinant, E. coli

444324
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₁₇₈H₂₈₆N₅₂O₅₀S₇145808-47-5
      Description
      Overview

      This product has been discontinued.





      A recombinant peptide expressed in and extracted from E. coli. Bioassay: inhibition of Kv1.3 K+ channels: <1 nM.
      Catalogue Number444324
      Brand Family Calbiochem®
      SynonymsrMgTx
      References
      ReferencesFischer, H.S., and Saria, A. 1999. Neurosci. Lett. 263, 208.
      Garcia-Calvo, M., et al. 1993. J. Biol. Chem. 268, 18866.
      Leonard, R.J., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 10094.
      Product Information
      CAS number145808-47-5
      FormLyophilized
      FormulationSalt free.
      Hill FormulaC₁₇₈H₂₈₆N₅₂O₅₀S₇
      Chemical formulaC₁₇₈H₂₈₆N₅₂O₅₀S₇
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Peptide SequenceH-Thr-Ile-Ile-Asn-Val-Lys-Cys⁷-Thr-Ser-Pro-Lys-Gln-Cys¹³-Leu-Pro-Pro-Cys¹⁷-Lys-Ala-Gln-Phe-Gly-Gln-Ser-Ala-Gly-Ala-Lys-Cys²⁹-Met-Asn-Gly-Lys-Cys³⁴-Lys-Cys³⁶-Tyr-Pro-His-OH (disulfide 7 →29; 13 →34; 17 → 36)
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      444324

      References

      Reference overview
      Fischer, H.S., and Saria, A. 1999. Neurosci. Lett. 263, 208.
      Garcia-Calvo, M., et al. 1993. J. Biol. Chem. 268, 18866.
      Leonard, R.J., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 10094.

      Brochure

      Title
      Channel Blockers Technical Bulletin
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-August-2008 RFH
      SynonymsrMgTx
      DescriptionVoltage-dependent K+ channel blocker that is specific for the Kv1.3 channel. Blocks N-type current of human T lymphocytes (IC50 = 50 pM). Has no effect on Ca2+ activated channels. Enhances spontaneous release of acetylcholine in rat striatal slices.
      FormLyophilized
      FormulationSalt free.
      CAS number145808-47-5
      Chemical formulaC₁₇₈H₂₈₆N₅₂O₅₀S₇
      Peptide SequenceH-Thr-Ile-Ile-Asn-Val-Lys-Cys⁷-Thr-Ser-Pro-Lys-Gln-Cys¹³-Leu-Pro-Pro-Cys¹⁷-Lys-Ala-Gln-Phe-Gly-Gln-Ser-Ala-Gly-Ala-Lys-Cys²⁹-Met-Asn-Gly-Lys-Cys³⁴-Lys-Cys³⁶-Tyr-Pro-His-OH (disulfide 7 →29; 13 →34; 17 → 36)
      Purity≥98% by HPLC
      SolubilityReconstitute in 0.1% BSA, 100 mM NaCl, 10 mM Tris, pH 7.5, 1 mM EDTA. Add 0.01% BSA to experimental solutions before applying the toxin.
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesFischer, H.S., and Saria, A. 1999. Neurosci. Lett. 263, 208.
      Garcia-Calvo, M., et al. 1993. J. Biol. Chem. 268, 18866.
      Leonard, R.J., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 10094.