444289 | Marimastat - CAS 154039-60-8 - Calbiochem

444289
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₁₅H₂₉N₃O₅154039-60-8

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      444289-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewAn orally active peptidyl hydroxamate-based broad-spectrum MMP inhibitor (IC50 in nM = 5, 6, 200, 20, 2, 1.8 and 3.8 for MMP-1, -2, -3, -7, -8, -14 and TACE, respectively) that targets both the substrate binding site and the active-site Zn2+. Marimastate is widely used in studying the involvement of MMPs in various cellular and pathological processes both in vitro and in vivo.
          Catalogue Number444289
          Brand Family Calbiochem®
          Synonyms(2S,3R)-N⁴-((1S)-2,2-Dimethyl-1-((methylamino)carbonyl)propyl)-N¹,2-hydroxy-3-(2-methylpropyl)butanediamide, BB-2516
          References
          ReferencesHansen, H.P., et al. 2002. Int. J. Cancer 98, 210.
          Tsuji, F., et al. 2002. Cytokine 17, 294.
          Barlaam, B., et al. 1999. J. Med. Chem. 42, 4890.
          Whittaker, M., et al. 1999. Chem. Rev. 99, 2735.
          Rasmussen, H.S., and McCann, P.P. 1997. Pharmacol. Ther. 75, 69.
          Product Information
          CAS number154039-60-8
          FormWhite solid
          Hill FormulaC₁₅H₂₉N₃O₅
          Chemical formulaC₁₅H₂₉N₃O₅
          Structure formula Image
          Applications
          ApplicationMarimastat, CAS 154039-60-8, is a broad-spectrum MMP inhibitor (IC50 = 5, 6, 200, 20, 2, 1.8 & 3.8 nM for MMP-1, -2, -3, -7, -8, -14 and TACE, respectively).
          Biological Information
          Purity≥98% by NMR
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          S PhraseS: 22-24/25-36/37/39

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Wear suitable protective clothing, gloves and eye/face protection.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          444289

          References

          Reference overview
          Hansen, H.P., et al. 2002. Int. J. Cancer 98, 210.
          Tsuji, F., et al. 2002. Cytokine 17, 294.
          Barlaam, B., et al. 1999. J. Med. Chem. 42, 4890.
          Whittaker, M., et al. 1999. Chem. Rev. 99, 2735.
          Rasmussen, H.S., and McCann, P.P. 1997. Pharmacol. Ther. 75, 69.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision25-August-2009 RFH
          Synonyms(2S,3R)-N⁴-((1S)-2,2-Dimethyl-1-((methylamino)carbonyl)propyl)-N¹,2-hydroxy-3-(2-methylpropyl)butanediamide, BB-2516
          DescriptionAn orally active peptidyl hydroxamate-based broad-spectrum MMP inhibitor (IC50 in nM = 5, 6, 200, 20, 2, 1.8 and 3.8 for MMP-1, -2, -3, -7, -8, -14 and TACE, respectively) that targets both the substrate binding site and the active-site Zn2+. Marimastate is widely used in studying the involvement of MMPs in various cellular and pathological processes both in vitro and in vivo.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number154039-60-8
          Chemical formulaC₁₅H₂₉N₃O₅
          Structure formula
          Purity≥98% by NMR
          SolubilityDMSO (15 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesHansen, H.P., et al. 2002. Int. J. Cancer 98, 210.
          Tsuji, F., et al. 2002. Cytokine 17, 294.
          Barlaam, B., et al. 1999. J. Med. Chem. 42, 4890.
          Whittaker, M., et al. 1999. Chem. Rev. 99, 2735.
          Rasmussen, H.S., and McCann, P.P. 1997. Pharmacol. Ther. 75, 69.