445800 | Merbarone - CAS 97534-21-9 - Calbiochem

445800
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₁₁H₉N₃O₃S97534-21-9

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      445800-25MG
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          Plastic ampoule 25 mg
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          Description
          OverviewA cell-permeable anticancer drug that inhibits the catalytic activity of topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes (IC50 = 20 µM for purified mammalian topo II versus IC50 = ~ 200 µM for topo I). Also induces apoptosis in human leukemic CEM cells through a caspase-3-like protease-dependent mechanism.
          Catalogue Number445800
          Brand Family Calbiochem®
          Synonyms5-(N-Phenylcarboxamido)-2-thiobarbituric Acid, NSC-336628
          References
          ReferencesKhelifa, T., and Beck, W.T. 1999. Mol. Pharmacol. 55, 548.
          Drake, F.H., et al. 1989. Cancer Res. 49, 2578.
          Brewer, A.D., et al. 1985. Biochem. Pharmacol. 34, 2047.
          Product Information
          CAS number97534-21-9
          ATP CompetitiveN
          FormFaint pink solid
          Hill FormulaC₁₁H₉N₃O₃S
          Chemical formulaC₁₁H₉N₃O₃S
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCatalytic activity of topoisomerase II
          Primary Target IC<sub>50</sub>20 µM for purified topoisomerase II (topo II)
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSUV7714625
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          445800

          References

          Reference overview
          Khelifa, T., and Beck, W.T. 1999. Mol. Pharmacol. 55, 548.
          Drake, F.H., et al. 1989. Cancer Res. 49, 2578.
          Brewer, A.D., et al. 1985. Biochem. Pharmacol. 34, 2047.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-August-2008 RFH
          Synonyms5-(N-Phenylcarboxamido)-2-thiobarbituric Acid, NSC-336628
          DescriptionA cell-permeable, anticancer drug that inhibits the catalytic activity of DNA topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes (IC50 = 20 µM for purified mammalian topoisomerase II versus IC50 ~200 µM for topoisomerase I). Also induces apoptosis in human leukemic CEM cells through a caspase-3-like protease-dependent mechanism.
          FormFaint pink solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number97534-21-9
          RTECSUV7714625
          Chemical formulaC₁₁H₉N₃O₃S
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Toxicity Standard Handling
          ReferencesKhelifa, T., and Beck, W.T. 1999. Mol. Pharmacol. 55, 548.
          Drake, F.H., et al. 1989. Cancer Res. 49, 2578.
          Brewer, A.D., et al. 1985. Biochem. Pharmacol. 34, 2047.