FCMAB418PE | Milli-Mark™ Anti-CAR-PE Antibody, clone RmcB

FCMAB418PE
100 tests  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFCMPhycoerythrinMonoclonal Antibody
      Description
      Catalogue NumberFCMAB418PE
      Trade Name
      • Milli-Mark
      DescriptionMilli-Mark™ Anti-CAR-PE Antibody, clone RmcB
      Alternate Names
      • 46 kD coxsackievirus and adenovirus receptor (CAR) protein
      • CVB3 binding protein
      • CVB3-binding protein
      • Coxsackievirus B-adenovirus receptor
      • coxsackie virus B receptor
      • coxsackie virus and adenovirus receptor
      Background InformationThe coxsackievirus and adenovirus receptor (CAR) mediates cell attachment and infection by coxsackie B viruses and by a number of adenoviruses. CAR also mediates homotypic intercellular interactions. In polarized epithelial cells, CAR is closely associated with the tight junction, where it contributes to the barrier to paracellular flow of solutes and macromolecules. CAR's biological roles are not well defined, but emerging evidence suggests that it may function during embryonic development and in regulating cell proliferation.
      References
      Product Information
      FormatPhycoerythrin
      Control
      • HT-29 cells
      PresentationPurified mouse monoclonal IgG1 conjugated to PE in PBS with 0.1% sodium azide and 15 mg/mL BSA.
      Applications
      ApplicationDetect CAR using this Milli-Mark Anti-CAR-PE Antibody, clone RmcB validated for use in FC.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenNative human coxsackie virus-adenovirus receptor protein
      CloneRmcB
      HostMouse
      SpecificityAntibody recognizes CAR.
      IsotypeIgG1
      Species Reactivity
      • Human
      Species Reactivity NoteTested and passed on Human. Unconjugated version Cat. No. 05-644 is known to react with Mouse and Rat.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CXADR
      • CAR
      • hCAR
      • HCVADR
      • HCAR
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P78310 # Receptor for group B coxsackieviruses and subgroup C of adenoviruses (AD2 and AD5), susceptibility to infection is correlated to its level of expression and availability at the plasma membrane of cells.

      SIZE: 365 amino acids; 40030 Da

      SUBUNIT: Monomer. Probably homodimer formed by 2 molecules on adjacent cells. Interacts with LNX, MPDZ, BAIAP1, DLG4, PRKCABP, TJP1 and CTNNB1. Secreted isoform 3, isoform 4 and isoform 5 can interact with the extracellular domain of the receptor. Binds adenovirus 12 fiber protein. Isoform 5 but not isoform 3 binds to coxsackievirus.

      SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. Note=In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions. In airway epithelial cells localized to basolateral membrane but not to apical surface. & Isoform 2: Cell membrane; Single-pass type I membrane protein. Note=In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions. In airway epithelial cells localized to basolateral membrane but not to apical surface. & Isoform 3: Secreted. & Isoform 4: Secreted. & Isoform 5: Secreted.

      TISSUE SPECIFICITY: Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitoulsy expressed while isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy.

      DOMAIN: SwissProt: P78310 The Ig-like C2-type 1 domain probably mediates homodimerization and interaction with JAML. & The PDZ-binding motif mediates interaction with MPDZ and BAIAP1.

      PTM: N-glycosylated (By similarity). & Palmitoylated on Cys-259 and/or Cys-260; required for proper localization to the plasma membrane.

      SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
      Molecular Weight40 kDa Calculated. Uniprot indicates multiple isoforms ranging from 9 to 40 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by flow cytometry using HT-29 cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 tests
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Milli-Mark Anti-CAR-PE, clone RmcB - 2118975 2118975
      Milli-Mark Anti-CAR-PE, clone RmcB - 2142682 2142682
      Milli-Mark Anti-CAR-PE, clone RmcB - 2006383 2006383
      Milli-Mark Anti-CAR-PE, clone RmcB - 2059928 2059928
      Milli-Mark Anti-CAR-PE, clone RmcB - 2095624 2095624
      Milli-Mark Anti-CAR-PE, clone RmcB - 2106928 2106928
      Milli-Mark Anti-CAR-PE, clone RmcB - 2168287 2168287
      Milli-Mark Anti-CAR-PE, clone RmcB - 2189732 2189732
      Milli-Mark Anti-CAR-PE, clone RmcB - 2211975 2211975
      Milli-Mark Anti-CAR-PE, clone RmcB - 2234213 2234213

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies