FCMAB168P | Milli-Mark Anti-CD3 -PE Antibody, clone UCHT1

FCMAB168P
100 tests  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFCMPhycoerythrinMonoclonal Antibody
      Description
      Catalogue NumberFCMAB168P
      Trade Name
      • Milli-Mark
      DescriptionMilli-Mark Anti-CD3 -PE Antibody, clone UCHT1
      Alternate Names
      • T-cell receptor
      Background InformationHuman TCR/CD3 is a complex structure on the lymphocyte surface. It consists of the TCR alpha beta or TCR gamma delta heterodimer and the associated CD3 complex. The CD3 complex is composed of six polypeptides with usually four different transmembrane CD3 chains, gamma, delta, epsilon. and zeta. Three different dimers, gamma epsilon, delta epsilon, and zeta zeta, constitute the CD3 complex. The MW of CD3epsilon is 20 000 (Campana, 1987). CD3 is first detectable in early thymocytes and its appearance probably represents one of the earliest signs of commitment to the T cell lineage. In cortical thymocytes, during early stages of maturation, the CD3 antigen is predominantly present in the cell cytoplasm. In medullary thymocyles, the CD3 antigen is predominantly detected on the cell surface (Swerdlow, 1988; Beverley, 1981). The majority of T cell neoplasms also expresses CD3, but it is absent from non-T-cell lymphoid malignancies (McMichael, 1987). Consistent with the pattern of synthesis of the antigen in normal thymocytes, the earliest site detectable within neoplastic cells is the cell cytoplasm (Swerdlow, 1988).
      References
      Product Information
      FormatPhycoerythrin
      Control
      • Human Lymphocytes
      PresentationPurified Mouse monoclonal IgG1 conjugated to PE in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2
      Applications
      ApplicationMilli-Mark Anti-CD3 -PE Antibody, clone UCHT1 is an antibody against CD3 for use in FC.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenHuman infant thymocytes and lymphocytes from a patient with Sézary disease.
      CloneUCHT1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityAntibody recognizes Human CD3 antigen.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Purification MethodProtein A Purfied
      UniProt Number
      Molecular Weight 20 kDa (Campana, 1987)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by flow cytometry using Human Lymphocytes.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 tests
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Milli-Mark Anti-CD3 -PE, clone UCHT1 - 2106922 2106922
      Milli-Mark Anti-CD3 -PE, clone UCHT1 - NRG1762703 NRG1762703
      Milli-Mark™ Anti-CD3 -PE, clone UCHT1 -2853596 2853596
      Milli-Mark™ Anti-CD3 -PE, clone UCHT1 -2854160 2854160
      Milli-Mark™ Anti-CD3 -PE, clone UCHT1 - 2376457 2376457
      Milli-Mark™ Anti-CD3 -PE, clone UCHT1 - 2384750 2384750
      Milli-Mark™ Anti-CD3 -PE, clone UCHT1 - 2390565 2390565
      Milli-Mark™ Anti-CD3 -PE, clone UCHT1 - 2445042 2445042
      Milli-Mark™ Anti-CD3 -PE, clone UCHT1 - 2446946 2446946
      Milli-Mark™ Anti-CD3 -PE, clone UCHT1 - 2275636 2275636

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies