FCABS376PE | Milli-Mark™ Anti-HMGB1/HMG-1-PE Antibody

FCABS376PE
100 tests  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, PoFCRbPhycoerythrinPolyclonal Antibody
      Description
      Catalogue NumberFCABS376PE
      Trade Name
      • Milli-Mark
      DescriptionMilli-Mark™ Anti-HMGB1/HMG-1-PE Antibody
      Alternate Names
      • High mobility group protein 1
      • Sulfoglucuronyl carbohydrate binding protein
      • high mobility group box 1
      • high-mobility group (nonhistone chromosomal) protein 1
      • high-mobility group box 1
      Background InformationHMG-1 (High-Mobility-Group protein, amphoterin) is a highly conserved protein with more than 95% amino acid identity between rodent and human HMG-1. It is a prevalent non-histone chromatin component and a non-sequence specific DNA binding protein. HMG-1 consists of two homologous HMG boxes rich in basic amino acids and an acidic tail at the carboxy-terminus. HMG-1 is involved in the regulation of chromatin structure as well as being involved, either as positive or negative factors with various aspects of DNA replication, transcription, repair, and ligation. HMG-1, identified as a membrane associated protein termed “amphoterin,” mediates neurite outgrowth, tumor outgrowth, and metastasis. It participates in plasminogen activation and is recognized as a late mediator of endotoxin lethality in mice.
      References
      Product Information
      FormatPhycoerythrin
      Control
      • HeLa cells
      PresentationPurified rabbit polyclonal IgG conjugated to PE in PBS with 0.1% sodium azide and 15 mg/mL BSA.
      Applications
      ApplicationMilli-Mark Anti-HMGB1/HMG-1-PE Antibody is an antibody against HMGB1/HMG-1 for use in FC.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenHMGB1/HMG-1 protein purified from pig thymus glands.
      HostRabbit
      SpecificityAntibody recognizes Human HMGB1/HMG-1.
      IsotypeIgG
      Species Reactivity
      • Human
      • Pig
      Species Reactivity NoteTested and passed on Human. Predicted to react with Pig based on immunogen design.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • HMGB1
      • HMG1
      • Amphoterin
      • DKFZp686A04236
      • HMG3
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryDNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells
      Molecular Weight25 kDa Calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by flow cytometry using HeLa cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 tests
      Transport Information
      Supplemental Information
      Specifications