FCMAB341F | Milli-Mark® Anti-Reelin-FITC, a.a. 164-496 Antibody, clone G10

FCMAB341F
100 tests  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MFCMFITCMonoclonal Antibody
      Description
      Catalogue NumberFCMAB341F
      Trade Name
      • Milli-Mark
      DescriptionMilli-Mark® Anti-Reelin-FITC, a.a. 164-496 Antibody, clone G10
      Background InformationThe highly layered structure of the cerebral cortex is established through the pattern of neuronal cell migrations. The first step is the creation of the primordial layer, the preplate, consisting of radial glial cells and the earliest generated neurons. Among these neurons are the Cajal-Retzius neurons. In the next step, the preplate splits into a superficial (marginal) zone, where the Cajal-Retzius neurons reside, and a deep subplate wherein the neurons form. Neurons migrating from the subplate form the cortical plate. This migration takes place on the radial glial fibers.

      The reeler mutant in mouse displays an abnormal pattern of cell migration throughout the cerebral and cerebellar cortices. The preplate forms normally, and the neurons differentiate at the correct times in the ventricular zone. However, instead of forming the normal "inside-out" arrangement of neurons in the cortical plate, the older neurons are found furthest from the ventricular zone, while the younger neurons do not migrate far at all. The reeler cerebral cortex is inverted from that of the wild type mouse.

      The defect of the reeler mice appears to be in the production of an extracellular matrix protein by the Cajal-Retzius cells (D'Arcangelo et al., 1995, Nature 374:719-723.; Ogawa et al., 1995 Neuron 14:899-912.) This 388kDa protein is made by wild-type mice but not by the reeler mutants. It is thought that this Reelin protein is crucial for positioning the migrating neuron within the cortical plate (Figure 1). In the absence of Reelin, the migrating neuron would be "lost," and the cortical plate would be abnormal. We do not yet know the mechanisms by which Reelin informs the cells as to their position, how the cell responds to Reelin, and why the absence of reelin should give an "inverted" plate. However, the identification of the protein encoded by the reeler gene should allow us to begin these studies.
      References
      Product Information
      FormatFITC
      Control
      • A431 cells
      PresentationPurified mouse monoclonal IgG1 conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
      Applications
      ApplicationDetect Milli-Mark Reelin-FITC, a.a. 164-496 using this Milli-Mark Anti-Reelin-FITC, a.a. 164-496 Antibody, clone G10 validated for use in Flow Cytometry.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenRecombinant reelin amino acids 164-496
      Epitopea.a. 164-496 mreelin
      CloneG10
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteDemonstrated to react with Human. Predicted to react with Mouse and Rat based on 100% sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • RELN
      • reelin
      • RL
      • EC 3.4.21.-
      Purification MethodProtein A Purfied
      UniProt Number
      Molecular Weight388 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by flow cytometry using A431 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 tests
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Milli-Mark Anti-Reelin-FITC, a.a. 164-496, clone G10 - 2197849 2197849
      Milli-Mark Anti-Reelin-FITC, a.a. 164-496, clone G10 - 2246794 2246794
      Milli-Mark#174; Anti-Reelin-FITC, a.a. 164- 496, clone G10 - Q2075187 Q2075187
      Milli-Mark™ Anti-Reelin-FITC, a.a. 164-496, clone G10 -2499188 2499188
      Milli-Mark™ Anti-Reelin-FITC, a.a. 164-496, clone G10 -2526214 2526214
      Milli-Mark™ Anti-Reelin-FITC, a.a. 164-496, clone G10 -2702155 2702155
      Milli-Mark™ Anti-Reelin-FITC, a.a. 164-496, clone G10_2849479 2849479
      Milli-Mark™ Anti-Reelin-FITC, a.a. 164-496, clone G10 - 2435677 2435677
      Milli-Mark™ Anti-Reelin-FITC, a.a. 164-496, clone G10 - 2450074 2450074

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies