FCMAB427F | Milli-Mark® Anti-mouse CD8-FITC Antibody, clone 3.155

FCMAB427F
100 tests  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MFCRFITCMonoclonal Antibody
      Description
      Catalogue NumberFCMAB427F
      Trade Name
      • Milli-Mark
      DescriptionMilli-Mark® Anti-mouse CD8-FITC Antibody, clone 3.155
      Alternate Names
      • CD8a molecule
      • CD8 antigen, alpha polypeptide (p32)
      • CD8 antigen alpha polypeptide
      • OKT8 T-cell antigen
      • T-lymphocyte differentiation antigen T8/Leu-2
      • Leu2 T-lymphocyte antigen
      • T-cell surface glycoprotein CD8 alpha chain
      • T-cell antigen Leu2
      • T8 T-cell antigen
      • T cell co-receptor
      • CD8a antigen
      Background InformationCD8, a member of the immunoglobulin superfamily, is expressed on the majority of thymocytes, a subset of mature T lymphocytes, and NK cells (almost exclusively CD8a homodimers). CD8a acts as a co-receptor with MHC class I-restricted T cell receptors, and through its association with protein tyrosine kinase p56Ick, modulates antigen recognition and T cell activation as well as thymic development.
      References
      Product Information
      FormatFITC
      Control
      • mouse splenocytes
      PresentationPurified rat monoclonal IgMk conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
      Applications
      ApplicationDetect mouse CD8 using this Milli-Mark Anti-mouse CD8-FITC Antibody, clone 3.155 validated for use in FC.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenCloned mouse cytolytic T cells.
      Clone3.155
      HostRat
      SpecificityAntibody recognizes mouse CD8a.
      IsotypeIgMκ
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • MAL
      • p322
      • CD8
      • CD8a
      • Leu2
      Purification MethodIon Exchange Purification
      UniProt Number
      UniProt SummaryFUNCTION: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.

      SUBUNIT STRUCTURE: In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers.

      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

      SEQUENCE SIMILARITIES: Contains 1 Ig-like V-type (immunoglobulin-like) domain.
      Molecular Weight27 kDa Calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by flow cytometry using mouse splenocytes.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 tests
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Milli-Mark#174; Anti-mouse CD8-FITC, clone 3.155 - NRG1937010 NRG1937010
      Milli-MarkAnti-mouse CD8-FITC, clone 3.155 - 2187394 2187394
      Milli-MarkAnti-mouse CD8-FITC, clone 3.155 - 2251773 2251773
      Milli-MarkAnti-mouse CD8-FITC, clone 3.155 - 2266769 2266769
      Milli-Mark™Anti-mouse CD8-FITC, clone 3.155 2474213
      Milli-Mark™Anti-mouse CD8-FITC, clone 3.155 2478925
      Milli-Mark™Anti-mouse CD8-FITC, clone 3.155 -2574660 2574660
      Milli-Mark™Anti-mouse CD8-FITC, clone 3.155 - 2376698 2376698
      Milli-Mark™Anti-mouse CD8-FITC, clone 3.155 - 2287215 2287215

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies