FCMAB390F | Milli-Mark® Anti-pan Histone-FITC Antibody, clone H11-4

FCMAB390F
100 tests  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFCMFITCMonoclonal Antibody
      Description
      Catalogue NumberFCMAB390F
      Trade Name
      • Milli-Mark
      DescriptionMilli-Mark® Anti-pan Histone-FITC Antibody, clone H11-4
      Background InformationThere are 5 main histone proteins involved in the structure of chromatin in eukaryotic cells. The five major classes of histones are H1/H5, H2A, H2B, H3, and H4. Histones H2A, H2B, H3 and H4 are known as the core histones, while histones H1 and H5 are known as the linker histones. Histones feature a main globular domain and a long N terminal tail which are involved with the structure of the nucleosomes of the 'beads on a string' structure. They are the chief protein components of chromatin, acting as spools around which DNA winds, and play a role in gene regulation.
      References
      Product Information
      FormatFITC
      Control
      • HeLa cells
      PresentationPurified mouse monoclonal IgG1 conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
      Applications
      ApplicationThis Milli-Mark Anti-pan Histone-FITC Antibody, clone H11-4 is validated for use in FC for the detection of pan Histone.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenPurified nuclear fractions of HeLa cells
      CloneH11-4
      HostMouse
      SpecificityThe antibody binds specifically to an antigen determinant, which is present on all five histone proteins. The antibody recognizes the histones H1, H2A, H2B, H3 and H4 with comparable sensitivity.
      IsotypeIgG1
      Species Reactivity
      • Human
      Species Reactivity NoteDue to the highly conserved nature of histones, this antibody is predicted to have wide species reactivity.
      Antibody TypeMonoclonal Antibody
      Purification MethodProtein A Purfied
      Molecular WeightAntibody recognizes histones H1, H2A, H2B, H3, and H4. Calculated molecular weight for these histones range from 14 to 21 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by flow cytometry using HeLa cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 tests
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Milli-Mark Anti-pan Histone-FITC, clone H11-4 - 2203081 2203081
      Milli-Mark#174; Anti-pan Histone-FITC, clone H11-4 - 2117153 2117153
      Milli-Mark#174; Anti-pan Histone-FITC, clone H11-4 - Q1963297 Q1963297
      Milli-Mark™ Anti-pan Histone-FITC, -2822545 2822545
      Milli-Mark™ Anti-pan Histone-FITC, clone H11-4 2485961
      Milli-Mark™ Anti-pan Histone-FITC, clone H11-4 -2603259 2603259
      Milli-Mark™ Anti-pan Histone-FITC, clone H11-4 -2673189 2673189
      Milli-Mark™ Anti-pan Histone-FITC, clone H11-4 - 2290250 2290250
      Milli-Mark™ Anti-pan Histone-FITC, clone H11-4 - 2330628 2330628

      Brochure

      Title
      New Products: Volume 3, 2012