203996 | N-Butyldeoxynojirimycin, Hydrochloride - CAS 72599-27-0 - Calbiochem

203996
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₁₀H₂₁NO₄ · HCl72599-27-0

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      203996-10MG
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      In Stock 
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          Plastic ampoule 10 mg
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          Description
          OverviewA non-hormonal, alkylated iminosugar that acts as a transition state analog inhibitor of ceramide-specific glycosyltransferases and ER α-glucosidases I and II. Displays a broad-spectrum anti-viral activity by aiding the misfolding of glycoproteins. Shown to reversibly induce infertility in male mammals. Does not inhibit cell proliferation.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number203996
          Brand Family Calbiochem®
          SynonymsNB-DNJ, HCl, N-Butyl-DNJ, HCl
          References
          ReferencesDwek, R.A., et al. 2002. Nat. Rev. Drug Discovery 1, 65.
          van der Spoel, A.C., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 17173.
          Platt, F.M., et al. 1997. Science 276, 428.
          Block, T.M., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 2235.
          Platt, F.M., et al. 1994. J. Biol. Chem. 269, 8362.
          Product Information
          CAS number72599-27-0
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₀H₂₁NO₄ · HCl
          Chemical formulaC₁₀H₂₁NO₄ · HCl
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCeramide-specific glycosyltransferases
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          203996

          References

          Reference overview
          Dwek, R.A., et al. 2002. Nat. Rev. Drug Discovery 1, 65.
          van der Spoel, A.C., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 17173.
          Platt, F.M., et al. 1997. Science 276, 428.
          Block, T.M., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 2235.
          Platt, F.M., et al. 1994. J. Biol. Chem. 269, 8362.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision21-November-2014 JSW
          SynonymsNB-DNJ, HCl, N-Butyl-DNJ, HCl
          DescriptionA non-hormonal, alkylated imino sugar that acts as a transition state analog inhibitor of ceramide-specific glycosyltransferases and ER α-glucosidases I and II. Displays broad-spectrum anti-viral effects by inhibiting the processing of viral surface glycoproteins. Shown to reversibly induce infertility in male mammals.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number72599-27-0
          Chemical formulaC₁₀H₂₁NO₄ · HCl
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityH₂O (1 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesDwek, R.A., et al. 2002. Nat. Rev. Drug Discovery 1, 65.
          van der Spoel, A.C., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 17173.
          Platt, F.M., et al. 1997. Science 276, 428.
          Block, T.M., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 2235.
          Platt, F.M., et al. 1994. J. Biol. Chem. 269, 8362.