487925 NBQX

487925
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₁₂H₈N₄O₆S118876-58-7
      Description
      Overview

      This product has been discontinued.





      Potent, competitive, and selective AMPA receptor antagonist that is effective at nanomolar concentrations (Kd = 47 nM). Acts as a neuroprotectant.
      Catalogue Number487925
      Brand Family Calbiochem®
      SynonymsFG 9202, 6-Nitro-7-sulphamoylbenzo[f]quinoxaline-2,3-dione, 2,3-Dihydroxy-6-nitro-7-sulphamoylbenzo[f]-quinoxaline
      References
      ReferencesDev, K.K., et al. 1996. J. Neurochem. 67, 2609.
      Brasko, J., et al. 1995. Brain Res. 699, 133.
      Yu, W., and Miller, R.F. 1995. Brain Res. 692, 190.
      Lees, G.J., and Leong, W. 1994. NeuroReport 5, 2149.
      Namba, T., et al. 1994. Brain. Res. 638, 36.
      Gill, R., et al. 1992. Brain Res. 580, 35.
      Product Information
      CAS number118876-58-7
      ATP CompetitiveN
      DeclarationSold under license from Novo Nordisk.
      FormYellow solid
      Hill FormulaC₁₂H₈N₄O₆S
      Chemical formulaC₁₂H₈N₄O₆S
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetAMPA receptor antagonist
      Primary Target IC<sub>50</sub>Kd = 47 nM against AMPA receptor
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      487925

      References

      Reference overview
      Dev, K.K., et al. 1996. J. Neurochem. 67, 2609.
      Brasko, J., et al. 1995. Brain Res. 699, 133.
      Yu, W., and Miller, R.F. 1995. Brain Res. 692, 190.
      Lees, G.J., and Leong, W. 1994. NeuroReport 5, 2149.
      Namba, T., et al. 1994. Brain. Res. 638, 36.
      Gill, R., et al. 1992. Brain Res. 580, 35.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-August-2008 RFH
      SynonymsFG 9202, 6-Nitro-7-sulphamoylbenzo[f]quinoxaline-2,3-dione, 2,3-Dihydroxy-6-nitro-7-sulphamoylbenzo[f]-quinoxaline
      DescriptionPotent, competitive and selective AMPA receptor antagonist which is effective at nanomolar concentrations. Acts as a neuroprotectant.
      FormYellow solid
      CAS number118876-58-7
      Chemical formulaC₁₂H₈N₄O₆S
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO or methanol
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
      Toxicity Irritant
      ReferencesDev, K.K., et al. 1996. J. Neurochem. 67, 2609.
      Brasko, J., et al. 1995. Brain Res. 699, 133.
      Yu, W., and Miller, R.F. 1995. Brain Res. 692, 190.
      Lees, G.J., and Leong, W. 1994. NeuroReport 5, 2149.
      Namba, T., et al. 1994. Brain. Res. 638, 36.
      Gill, R., et al. 1992. Brain Res. 580, 35.