487928 | Nocodazole - CAS 31430-18-9 - Calbiochem

487928
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₁₄H₁₁N₃O₃S31430-18-9

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      487928-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewInhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also available as a 50 mM solution in DMSO (Cat. No. 487929).
          Catalogue Number487928
          Brand Family Calbiochem®
          SynonymsR17934, Methyl-[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamate
          References
          ReferencesPark, H., et al. 2011. Chem. Med. Chem. in press.
          Bunz, F., et al. 1998. Science 282, 1497.
          Fleischman, L.F., et al. 1993. Oncogene 8, 771.
          Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun. 189, 1429.
          Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.
          Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci. 103, 1167.
          Product Information
          CAS number31430-18-9
          ATP CompetitiveN
          FormPale yellow solid
          Hill FormulaC₁₄H₁₁N₃O₃S
          Chemical formulaC₁₄H₁₁N₃O₃S
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationNocodazole, CAS 31430-18-9, is a highly specific anti-microtubular agent that promotes tubulin depolymerization and inhibits mitosis.
          Biological Information
          Primary TargetPromotes tubulin depolymerization
          Purity≥99% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSDD6521000
          Safety Information
          R PhraseR: 40-63

          Limited evidence of a carcinogenic effect.
          Possible risk of harm to the unborn child.
          S PhraseS: 36

          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +15°C to +30°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 year at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          487928

          References

          Reference overview
          Park, H., et al. 2011. Chem. Med. Chem. in press.
          Bunz, F., et al. 1998. Science 282, 1497.
          Fleischman, L.F., et al. 1993. Oncogene 8, 771.
          Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun. 189, 1429.
          Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.
          Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci. 103, 1167.

          Citations

          Title
        • Meng Qiao, et al. (2006) Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation. Journal of Biological Chemistry 281, 7118-7128.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-June-2012 JSW
          SynonymsR17934, Methyl-[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamate
          DescriptionInhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also acts as a high-affinity ligand for the cancer-related kinases ABL, c-KIT, BRAF, and MEK (Kd < 2 µM).
          FormPale yellow solid
          CAS number31430-18-9
          RTECSDD6521000
          Chemical formulaC₁₄H₁₁N₃O₃S
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage +15°C to +30°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 year at -20°C.
          Toxicity Carcinogenic / Teratogenic
          ReferencesPark, H., et al. 2011. Chem. Med. Chem. in press.
          Bunz, F., et al. 1998. Science 282, 1497.
          Fleischman, L.F., et al. 1993. Oncogene 8, 771.
          Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun. 189, 1429.
          Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.
          Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci. 103, 1167.
          Citation
        • Meng Qiao, et al. (2006) Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation. Journal of Biological Chemistry 281, 7118-7128.