Non-cell-based Assays for Drug Transport

MultiScreen Permeability, MultiScreen-IP, and MultiScreen Acceptor plates support artificial membrane strategies for predicting passive transport.

Overview

Specifications

Ordering Information

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MultiScreen Permeability Plate with .45 µm Polycarbonate Membrane Clear Sorting & Filtering
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MPC4NTR10MultiScreen Permeability Filter Plate, 0.4 µm, non-sterile 10 Show Pricing & Availability

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MultiScreen-IP Plate with 0.45 µm PVDF Membrane (with underdrain) Clear Sorting & Filtering
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MAIPN4550MultiScreen-IP Filter Plate, 0.45 µm, clear, non-sterile 50 Show Pricing & Availability

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MultiScreen-IP Plate with 0.45 µm PVDF Membrane (without underdrain) Clear Sorting & Filtering
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MAIPNTR10MultiScreen IP Filter Plate, 0.45 µm, clear, non-sterile 10 Show Pricing & Availability

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MultiScreen Acceptor 96-well PTFE Clear Sorting & Filtering
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MSSACCEPT0RMultiScreen Acceptor Plate 1 Show Pricing & Availability

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Accessories Clear Sorting & Filtering
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MATRNPS50MultiScreen 96-well Transport Receiver Plate, non-sterile 50 Show Pricing & Availability
MSCPNUV4096-well MultiScreenHTS Collection Plate for UV analysis, non-sterile 40 Show Pricing & Availability

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    Documentation

    Technical Info

    Title
    Automation of HDM-PAMPA using a MultiScreen Permeability Plate on a Hamilton MICROLAB STAR Workstation
    Automation of PAMPA-HDM using a MultiScreen Filter Plate on a Beckman Biomek FX Workstation
    Automation of PAMPA-HDM using a MultiScreen Permeability Plate on a Tecan Freedom EVO Workstation
    Automation of PAMPA-Lipid using a MultiScreen-IP PAMPA Filter Plate on a ScicloneTM ALH 3000 Advanced Liquid Handler Workstation
    Combining Permeability and Solubility Analyses in a Single Workflow
    HDM-PAMPA with the MultiScreen Permeability Filter Plate
    Membrane Integrity test for Lipid-PAMPA Artificial Membranes
    MultiScreen Filter Plates for PAMPA: Evaluation of the reproducibility of Parallel Artificial Membrane Permeation Assays (PAMPA)
    MultiScreen Permeability Plates: The evaluation of the reproducibility of passive, transcellular drug permeability assays

    Data Sheet

    Title
    MultiScreen Transport and PTFE Receiver Plates

    Posters

    Title
    Automation of ADME Applications

    References

    Reference overview
    Relationship between structure and high-througput screening permability of diverse drugs with artifical membranes: Application to prediction of Caco-2 cell permeability.
    Masaaki Fujikawa, Rieko Ano, Kazuya Nakao, Ryo Shimizu and Miki Akamatsu
    Bioorganic & Medicinal Chemistry  2005

    A novel high-throughput automated chip-based nanoelectrospray tandem mass spectrometric method for PAMPA sample analysis.
    Balimane, P.V., Pace, E., Chong, S., Zhu, M., Jemal, M., VanPelt, C.K.
    Journal of Pharmaceutical and Biomedical Analysis 39 (2005): 8-16  2005

    Use of ADME screening to conserve resources in drug discovery and development
    Weiss, A. and Joseph Machamer
    American Biotechnology Laboratory, January 2004: 16-17  2004

    Screening for pharma gold: Researchers are using membrane technologies for high-throughput ADME analysis
    Lynch, John,Modern Drug Discovery, January 2004: 27-28
    Modern Drug Discovery, January 2004: 27-28  2004

    Relationships between structure and high-throughput screening permeability of peptide derivatives and related compounds with artificial membranes: application to prediction of Caco-2 cell permeability
    Rieko Ano, Yukitaka Kimura, Motohiro Shima, Ryuichi Matsuno, Tamio Ueno and Miki Akamatsu
    Bioorganic & Medicinal Chemistry 12 (2004) 257-264  2004

    Prediction of human intestinal permeability using artificial membrane permeability
    Kiyohiko Sugano, Yoshiaki Nabuchi, Minoru Machida and Yoshinori Aso
    International Journal of Pharmaceutics 257 (2003) 245-251  2003

    FAQ

    QuestionAnswer
    What material is the underdrain support to the Multiscreen plates made of?The underdrain support is made of polyethylene.
    What is the well depth and maximum volume capacity of a MultiScreen plate?The well depth of a 96 well MultiScreen plate is 1.245 cm. The well depth for a 384 well MultiScreen plate is 1.2 cm. The maximum working volume of a 96 well plate is 300 ul. The maximum working volume for a 384 well plate is 100 ul.

    User Guides

    Title
    MultiScreen Immobilon-P Filtration Plates
    MultiScreen Permeability Plate Assembly
    MultiScreen® 96-well Transport Receiver Plate User Guide
    MultiScreen® Permeability Filter Plate Assembly User Guide
    User Guide: MultiScreen® 96-well Plates