496915 | Oridonin, R. rubescens - CAS 28957-04-2 - Calbiochem

496915
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₂₀H₂₈O₆28957-04-2

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      496915-5MG
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      In Stock 
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable diterpenoid compound that possesses anti NF-κB activity and displays antiproliferative (ED50 = ~ 2.7 µg/ml in lymphoid malignant cells) and antiangiogenic properties (significantly inhibits network formation of HMEC-1 cells at 2.5 µg/ml). Reported to affect DNA synthesis, induce apoptosis and initiate cell cycle arrest. Shown to efficiently block both TNF-α and LPS-induced NF-κB activity in Jurkat and in RAW264.7 murine macrophages, and inhibit p65 NF-κB transcriptional activity (IC50 = ~ 5 µg/ml in MT-1 cells) by disrupting NF-κB DNA-binding activity without interfering with its nuclear translocation.
          Catalogue Number496915
          Brand Family Calbiochem®
          References
          ReferencesIkezoe, T., et al. 2005. Mol. Cancer Ther. 4, 578.
          Meade-Tollin, L.C., et al. 2004. J. Nat. Prod. 67, 2.
          Product Information
          CAS number28957-04-2
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₂₀H₂₈O₆
          Chemical formulaC₂₀H₂₈O₆
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetNF-κB transcriptional activity
          Primary Target IC<sub>50</sub>5 µg/ml inhibiting p65 NF-κB transcriptional activity in MT-1 cells
          Purity≥93% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSNZ8177000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          496915

          References

          Reference overview
          Ikezoe, T., et al. 2005. Mol. Cancer Ther. 4, 578.
          Meade-Tollin, L.C., et al. 2004. J. Nat. Prod. 67, 2.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision24-January-2017 JSW
          DescriptionA cell-permeable inhibitor of NF-κB activity that displays antiproliferative (ED50 ~ 2.7 µg/ml in lymphoid malignant cells) and antiangiogenic properties (significantly inhibits network formation of HMEC-1 cells at 2.5 µg/ml). Reported to affect DNA synthesis, induce apoptosis, and initiate cell cycle arrest. Shown to efficiently block both TNF-α and LPS-induced NF-κB activity in Jurkat and in RAW264.7 murine macrophages. Also inhibits p65 NF-κB transcriptional activity (IC50 ~5 µg/ml in MT-1 cells) by disrupting NF-κB DNA-binding activity without interfering with its nuclear translocation.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number28957-04-2
          RTECSNZ8177000
          Chemical formulaC₂₀H₂₈O₆
          Structure formulaStructure formula
          Purity≥93% by HPLC
          SolubilityDMSO (10 mg/ml). Use only fresh DMSO for reconstitution.
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesIkezoe, T., et al. 2005. Mol. Cancer Ther. 4, 578.
          Meade-Tollin, L.C., et al. 2004. J. Nat. Prod. 67, 2.