528120 | PIPER - CAS 213416-70-7 - Calbiochem

528120
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₃₈H₃₆N₄O₄213416-70-7

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      528120-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA perylene-based ligand that potently inhibits human telomerase by binding to G-quadruplex DNA. The strongest binding site for PIPER appears to be the 3′-boundary of the G-quadruplex. Can also bind non-specifically to nucleic acids. May also be useful as an antiproliferative agent.
          Catalogue Number528120
          Brand Family Calbiochem®
          SynonymsN,Nʹ-bis[2-(1-Piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic Diimide, Telomerase Inhibitor IV
          References
          ReferencesHan, H., et al. 1999. Biochemistry 38, 6981.
          Fedoroff, O.Y., et al. 1998. Biochemistry 37, 12367.
          Product Information
          CAS number213416-70-7
          ATP CompetitiveN
          FormDark purple solid
          Hill FormulaC₃₈H₃₆N₄O₄
          Chemical formulaC₃₈H₃₆N₄O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targethuman telomerase
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 20/21/22-40-68

          Harmful by inhalation, in contact with skin and if swallowed.
          Limited evidence of a carcinogenic effect.
          Possible risks of irreversible effects.
          S PhraseS: 22-36

          Do not breathe dust.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful & Carcinogenic / Teratogenic
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          528120

          References

          Reference overview
          Han, H., et al. 1999. Biochemistry 38, 6981.
          Fedoroff, O.Y., et al. 1998. Biochemistry 37, 12367.

          Brochure

          Title
          Caspases and other Apoptosis Related Tools Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision18-April-2011 RFH
          SynonymsN,Nʹ-bis[2-(1-Piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic Diimide, Telomerase Inhibitor IV
          DescriptionA perylene-based ligand that potently inhibits human telomerase by binding to G-quadruplex DNA. The strongest binding site for PIPER appears to be the 3'-boundary of the G-quadruplex. Can also bind non-specifically to nucleic acids. May be useful as an antiproliferative agent.
          FormDark purple solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number213416-70-7
          Chemical formulaC₃₈H₃₆N₄O₄
          Structure formulaStructure formula
          Purity≥95% by HPLC
          Solubility5% Acetic acid (50 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Toxicity Harmful & Carcinogenic / Teratogenic
          ReferencesHan, H., et al. 1999. Biochemistry 38, 6981.
          Fedoroff, O.Y., et al. 1998. Biochemistry 37, 12367.