476475 | PKC Inhibitor, EGF-R Fragment 651-658, Myristoylated - Calbiochem

476475
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₆₀H₁₁₇N₂₁O₁₁

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      476475-500UG
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      Limited AvailabilityLimited Availability
      In Stock 
      Discontinued
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          Plastic ampoule 500 μg
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          Description
          OverviewEpidermal growth-factor receptor (EGF-R) conserved sequence which is identical to v-ErbB (95-102). An N-terminal myristoylated membrane-permeable, reversible, and substrate competitive inhibitor of protein kinase C (IC50 = 5 µM).
          Catalogue Number476475
          Brand Family Calbiochem®
          SynonymsMyr-N-RKRTLRRL-OH, Myristoylated EGF-R Fragment (651-658), Protein Kinase C Inhibitor, Protein Kinase C Inhibitor, EGF-R Fragment 651-658, Myristoylated
          References
          ReferencesWard, N.E., and O’Brian, C.A. 1993. Biochemistry 32, 11903.
          O’Brian, C.A., et al. 1991. Invest. New Drugs 9, 169.
          Product Information
          ATP CompetitiveN
          FormLyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₆₀H₁₁₇N₂₁O₁₁
          Chemical formulaC₆₀H₁₁₇N₂₁O₁₁
          Hygroscopic Hygroscopic
          ReversibleY
          Sold on the basis of peptide contentY
          Applications
          Biological Information
          Primary TargetPKC
          Primary Target IC<sub>50</sub>5 µM against protein kinase C
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide ContentY
          Peptide SequenceMyr-N-Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu-OH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Moisture Protect from moisture
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          476475

          References

          Reference overview
          Ward, N.E., and O’Brian, C.A. 1993. Biochemistry 32, 11903.
          O’Brian, C.A., et al. 1991. Invest. New Drugs 9, 169.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-January-2010 RFH
          SynonymsMyr-N-RKRTLRRL-OH, Myristoylated EGF-R Fragment (651-658), Protein Kinase C Inhibitor, Protein Kinase C Inhibitor, EGF-R Fragment 651-658, Myristoylated
          DescriptionEpidermal growth-factor receptor (EGF-R) conserved sequence which is identical to v-erbB (95-102). An N-terminal myristoylated membrane-permeable, reversible, and substrate competitive inhibitor that inhibits protein kinase C (IC50 = 5 µM) in intact cells.
          FormLyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Chemical formulaC₆₀H₁₁₇N₂₁O₁₁
          Peptide SequenceMyr-N-Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu-OH
          Purity≥97% by HPLC
          SolubilityH₂O (5 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from moisture
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Toxicity Standard Handling
          ReferencesWard, N.E., and O’Brian, C.A. 1993. Biochemistry 32, 11903.
          O’Brian, C.A., et al. 1991. Invest. New Drugs 9, 169.