528285 | PLKtide

528285
  
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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.





      The 23 amino acid Cdc25C (182-204) sequence, containing PLK1 (polo-like kinase 1) phosphorylation sites Ser191 and Ser198, is modified between Ser191 and Ser198 as well as after Ser198 according to an optimized concensus sequence derived from 18 PLK1 substrate site sequences. PLK1/2/3 exhibit stronger preference (≥6-fold) for the second serine residue and phosphorylate PLKtide much more potently (≥10-fold) when compared with the parent Cdc25C (182-204) peptide, although PLKtide is not a substrate for PLK4.
      Catalogue Number528285
      Brand Family Calbiochem®
      References
      ReferencesJohnson, E.F., et al. 2007. Biochemistry 46, 9551.
      Product Information
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₀₃H₁₆₀N₂₄O₅₂
      Chemical formulaC₁₀₃H₁₆₀N₂₄O₅₂
      Hygroscopic Hygroscopic
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Peptide SequenceH-Leu-Gly-Glu-Asp-Gln-Ala-Glu-Glu-Ile-Ser-Asp-Asp-Leu-Leu-Glu-Asp-Ser-Leu-Ser-Asp-Glu-Asp-Glu-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      References

      Reference overview
      Johnson, E.F., et al. 2007. Biochemistry 46, 9551.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-April-2009 RFH
      DescriptionThe 23 amino acid Cdc25C (182-204) sequence, containing PLK1 (polo-like kinase 1) phosphorylation sites Ser191 and Ser198, is modified between Ser191 and Ser198 as well as after Ser198 according to an optimized concensus sequence derived from 18 PLK1 substrate site sequences. PLK1/2/3 exhibit stronger preference (≥6-fold) for the second serine residue and phosphorylate PLKtide much more potently (≥10-fold) when compared with the parent Cdc25C (182-204) peptide, although PLKtide is not a substrate for PLK4.
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₀₃H₁₆₀N₂₄O₅₂
      Peptide SequenceH-Leu-Gly-Glu-Asp-Gln-Ala-Glu-Glu-Ile-Ser-Asp-Asp-Leu-Leu-Glu-Asp-Ser-Leu-Ser-Asp-Glu-Asp-Glu-OH
      Purity≥95% by HPLC
      SolubilityH₂O (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Protect from moisture
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesJohnson, E.F., et al. 2007. Biochemistry 46, 9551.